Search Results
Overview
| Uniprot ID | F1SKI5 |
|---|---|
| Protein Name | Inosine-5'-monophosphate dehydrogenase |
| Gene Name | IMPDH2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 238 | RDYPLASKDAKKQLL |
| 242 | LASKDAKKQLLCGAA |
| 462 | FSEADKIKVAQGVSG |
| 474 | VSGAVQDKGSIHKFV |
| 535 | HSLHSYEKRLF**** |
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors
Protein Sequence
10
MADYLISGGT
20
SYVPDDGLTA
30
QQLFNCGDGL
40
TYNDFLILPG
50
YIDFTADQVD
60
LTSALTKKIT
70
LKTPLVSSPM
80
DTVTEAGMAI
90
AMALTGGIGF
100
IHHNCTPEFQ
110
ANEVRKVKKY
120
EQGFITDPVV
130
LSPKDRVRDV
140
FEAKAQHGFC
150
GIPITDTGRM
160
GSRLVGIISS
170
RDIDFLKEEE
180
HDRFLEEIMT
190
KREDLVVAPA
200
GITLKEANEI
210
LQRSKKGKLP
220
IVNEDDELVA
230
IIARTDLKKN
240
RDYPLASKDA
250
KKQLLCGAAI
260
GTHEDDKYRL
270
DLLAQAGVDV
280
VVLDSSQGNS
290
IFQINMIKYI
300
KEKYPSLQVI
310
GGNVVTAAQA
320
KNLIDAGVDA
330
LRVGMGSGSI
340
CITQEAAPKI
350
PPDIKSHSPK
360
CPSTVTGCYM
370
LACGRPQATA
380
VYKVSEYARR
390
FGVPVIADGG
400
IQNVGHIAKA
410
LALGASTVMM
420
GSLLAATTEA
430
PGEYFFSDGI
440
RLKKYRGMGS
450
LDAMDKHLSS
460
QNRYFSEADK
470
IKVAQGVSGA
480
VQDKGSIHKF
490
VPYLIAGIQH
500
SCQDIGAKSL
510
TQVRAMMYSG
520
ELKFEKRTSS
530
AQVEGGVHSL
HSYEKRLF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003938 | IMP dehydrogenase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0006177 | GMP biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.