Overview
| Uniprot ID | F1SKK1 |
|---|
| Protein Name | Mitochondrial carnitine/acylcarnitine carrier protein |
|---|
| Gene Name | SLC25A20 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 254 |
NGFRDVLKELIRNEG |
Function
Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism. Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation. Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange)
Protein Sequence
10
MADQAKPISP
20
LKNLLAGGFG
30
GMCLVFVGHP
40
LDTVKVRLQT
50
QPPSLPGQPP
60
MYSGTFDCFR
70
KTLMREGVRG
80
LYKGMAAPII
90
GVTPMFAVCF
100
FGFGLGKKLQ
110
QKHPEDVLSY
120
PQIFAAGMLS
130
GVFTTGIMTP
140
GERVKCLLQI
150
QASSGETKYN
160
GALDCAKKLY
170
RESGIRGIYK
180
GTVLTLMRDV
190
PASGMYFMTY
200
EWLKNTLTPE
210
GKSVSELSVP
220
RILLAGGIAG
230
IFNWAVAIPP
240
DVLKSRFQTA
250
PPGKYPNGFR
260
DVLKELIRNE
270
GITSLYKGFN
280
AVMIRAFPAN
290
AACFLGFEVA
300
MKFLNWITPN
L
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005740 |
mitochondrial envelope |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Molecular Function |
GO:0015227 |
O-acyl-L-carnitine transmembrane transporter activity |
| Biological Process |
GO:0006853 |
carnitine shuttle |
| Biological Process |
GO:1902603 |
carnitine transmembrane transport |
| Biological Process |
GO:0006839 |
mitochondrial transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.