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Overview

Uniprot ID	F1SKR7
Protein Name	Cell cycle checkpoint protein RAD17
Gene Name	RAD17
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
369	KSDAALSKSKRRQKP

Function

Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation. Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites. May also serve as a sensor of DNA replication progression

Protein Sequence

10 MSKTFLRPKV 20 SSTKVTDWVD 30 PSFDDFSETT 40 NISTINATSL 50 SVNNSSLRRK 60 KVPSTLESRR 70 SPTRKRGNLS 80 SSKQIYSLEN 90 SKEYVSENEP 100 WVDKYKPETQ 110 HELAVHKKKI 120 EEVETWLKVE 130 VLERQPTQGG 140 SILLITGPPG 150 CGKTATIKIL 160 SKEHGIQVQE 170 WINPVLPEFQ 180 KDDFKEIFNP 190 ESSFHIFPYQ 200 SQIAVFKEFL 210 LRATKYNKLQ 220 MLGDDLTTDK 230 KIILVEDLPN 240 QFYRDPHILH 250 EVLRRYVQVG 260 RCPLIFIISD 270 SLSGDNNHRL 280 LFPKEIQEEC 290 AISNISFNPV 300 APTIMMKFLN 310 RIVTKEANKN 320 GGKIIVPDKT 330 SLELLCQGCS 340 GDIRSAINSL 350 QFSSSTGKNN 360 LWPRKKGTSS 370 LKSDAALSKS 380 KRRQKPDRVF 390 ENQEVQAIGG 400 KDVSLFLFRA 410 LGKILYCKRA 420 SVTELDSPRL 430 PSHLSEYERD 440 TLLIHPEEVV 450 EMSHMPGDLF 460 NLYLHQNYVD 470 FFMDVDDLVR 480 ASEFLSFADI 490 LSGDWNTRSL 500 LREYSTSVAT 510 RGVIHSNRAR 520 GFANCQGGGS 530 SFRPLHKPQW 540 FLINKKYREN 550 CLAAKALFSD 560 FCLSPVCLQT 570 QLLPYLALLT 580 IPMRNQAQIS 590 FIQDIGRLPL 600 KRHFGRLKME 610 ALTDREHGMM 620 DLDSGDEAQL 630 GGGQPTEEAL 640 GEPTPSTEPE 650 PELLSLPLSQ 660 NSGSELPASQ 670 PRPFSAQGDM 680 EEEDMIIEDY ESDGT

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0031389	Rad17 RFC-like complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003689	DNA clamp loader activity
Biological Process	GO:0000077	DNA damage checkpoint signaling
Biological Process	GO:0006281	DNA repair

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.