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Overview

Uniprot IDF1SL54
Protein NameCoatomer subunit beta'
Gene NameCOPB2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
130 IKLWDWDKKWSCSQV
168 ASLDRTIKVWQLGSS
212 GADDRLVKIWDYQNK
318 NGKIIWAKHSEVQQA
413 RESNSVVKIFKNFKE
627 RVAHFLEKQGFKQQA
671 AESEQKWKQLAELAI
779 LWRENLSKVNQKAAE
822 HADLWPAKQYPLVTP

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors

Protein Sequence

10 MPLRLDIKRK 20 LTARSDRVKS 30 VDLHPTEPWM 40 LASLYNGSVC 50 VWNHETQTLV 60 KTFEVCDLPV 70 RAAKFVARKN 80 WVVTGADDMQ 90 IRVFNYNTLE 100 RVHMFEAHSD 110 YIRCIAVHPT 120 QPFILTSSDD 130 MLIKLWDWDK 140 KWSCSQVFEG 150 HTHYVMQIVI 160 NPKDNNQFAS 170 ASLDRTIKVW 180 QLGSSSPNFT 190 LEGHEKGVNC 200 IDYYSGGDKP 210 YLISGADDRL 220 VKIWDYQNKT 230 CVQTLEGHAQ 240 NVSCASFHPE 250 LPIIITGSED 260 GTVRIWHSST 270 YRLESTLNYG 280 MERVWCVASL 290 RGSNNVALGY 300 DEGSIIVKLG 310 REEPAMSMDA 320 NGKIIWAKHS 330 EVQQANLKAM 340 GDAEIKDGER 350 LPLAVKDMGS 360 CEIYPQTIQH 370 NPNGRFVVVC 380 GDGEYIIYTA 390 MALRNKSFGS 400 AQEFAWAHDS 410 SEYAIRESNS 420 VVKIFKNFKE 430 KKSFKPDFGA 440 ESIYGGFLLG 450 VRSVNGLAFY 460 DWDNTELIRR 470 IEIQPKHIFW 480 SDSGELVCIA 490 TEESFFILKY 500 LSEKVLAAQE 510 THEGVTEDGI 520 EDGFEVLGEI 530 QEIVKTGLWV 540 GDCFIYTSSV 550 NRLNYYVGGE 560 IVTIAHLDRT 570 MYLLGYIPKD 580 NRLYLGDKEL 590 NIVSYSLLVS 600 VLEYQTAVMR 610 RDFSMADKVL 620 PTIPKEQRTR 630 VAHFLEKQGF 640 KQQALTVSTD 650 PEHRFELALQ 660 LGELKIAYQL 670 AVEAESEQKW 680 KQLAELAISK 690 CQFGLAQECL 700 HHAQDYGGLL 710 LLATASGNAS 720 MVNKLAEGAE 730 RDGKNNVAFM 740 SYFLQGKLDA 750 CLELLIRTGR 760 LPEAAFLART 770 YLPSQVSRVV 780 KLWRENLSKV 790 NQKAAESLAD 800 PTEYENLFPG 810 LKEAFVVEEW 820 VKETHADLWP 830 AKQYPLVTPN 840 EERNVMEEAK 850 GFQPSRSAAQ 860 QELAGKPASP 870 TPVIMATHTG 880 NKEEKSLLEL 890 EVDLDNLELE 900 DIDTTDINLD EDILDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030663 COPI-coated vesicle membrane
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0030117 membrane coat
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.