Search Results
Overview
| Uniprot ID | F1SL99 |
|---|---|
| Protein Name | Prostaglandin E synthase 3 |
| Gene Name | PTGES3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 33 | DVNVNFEKSKLTFSC |
| 35 | NVNFEKSKLTFSCLG |
| 65 | CIDPNDSKHKRTDRS |
| 79 | SILCCLRKGESGQSW |
Function
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway
Protein Sequence
10
MQPASAKWYD
20
RRDYVFIEFC
30
VEDSKDVNVN
40
FEKSKLTFSC
50
LGGSDNFKHL
60
NEIDLFHCID
70
PNDSKHKRTD
80
RSILCCLRKG
90
ESGQSWPRLT
100
KERAKLNWLS
110
VDFNNWKDWE
120
DDSDEDMSNF
130
DRFSEMMNNM
140
GGDEDVDLPE
150
VDGADDDSQD
160
SDDEKMPDLE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0101031 | protein folding chaperone complex |
| Cellular Component | GO:0005697 | telomerase holoenzyme complex |
| Molecular Function | GO:0070182 | DNA polymerase binding |
| Molecular Function | GO:0051879 | Hsp90 protein binding |
| Molecular Function | GO:0050220 | prostaglandin-E synthase activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0003720 | telomerase activity |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0051131 | chaperone-mediated protein complex assembly |
| Biological Process | GO:0032212 | positive regulation of telomere maintenance via telomerase |
| Biological Process | GO:0001516 | prostaglandin biosynthetic process |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:1905323 | telomerase holoenzyme complex assembly |
| Biological Process | GO:0007004 | telomere maintenance via telomerase |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.