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Overview

Uniprot IDF1SLA0
Protein NameATP synthase subunit beta
Gene NameATP5F1B
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
123 APYAKGGKIGLFGGA
348 DVARGVQKILQDYKS
407 LGKLVPLKETIKGFQ
444 EAVAKADKLAEEHS*
46 EGLVRGQKVLDSGAP
55 LDSGAPIKIPVGPET

Function

Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain

Protein Sequence

10 MPPILNALEV 20 QGRETRLVLE 30 VAQHLGESTV 40 RTIAMDGTEG 50 LVRGQKVLDS 60 GAPIKIPVGP 70 ETLGRIMNVI 80 GEPIDERGPI 90 KTKQFAAIHA 100 EAPEFMEMSV 110 EQEILVTGIK 120 VVDLLAPYAK 130 GGKIGLFGGA 140 GVGKTVLIME 150 LINNVAKAHG 160 GYSVFAGVGE 170 RTREGNDLYH 180 EMIESGVINL 190 KDATSKVALV 200 YGQMNEPPGA 210 RARVALTGLT 220 VAEYFRDQEG 230 QDVLLFIDNI 240 FRFTQAGSEV 250 SALLGRIPSA 260 VGYQPTLATD 270 MGTMQERITT 280 TKKGSITSVQ 290 AIYVPADDLT 300 DPAPATTFAH 310 LDATTVLSRA 320 IAELGIYPAV 330 DPLDSTSRIM 340 DPNIVGSEHY 350 DVARGVQKIL 360 QDYKSLQDII 370 AILGMDELSE 380 EDKLTVSRAR 390 KIQRFLSQPF 400 QVAEVFTGHL 410 GKLVPLKETI 420 KGFQQILAGE 430 YDHLPEQAFY 440 MVGPIEEAVA 450 KADKLAEEHS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0045259 proton-transporting ATP synthase complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.