Search Results

Overview

Uniprot IDF1SLR6
Protein NameNucleolar protein 1
Gene NameNOP2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
422 DANAERLKSVVGNLH
481 VKTNKDEKDILRCAH
678 TKVQPSSKLQDSKQP
683 SSKLQDSKQPAEKAV
762 TTGAEKVKQQLPEQS
771 QLPEQSFKKTAFQKQ
79 PLPGKLPKGAVQTPS
802 SSRPPPAKRRKSQSR
88 AVQTPSKKGALSLFN

Function

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA. Required for efficient rRNA processing and 60S ribosomal subunit biogenesis. Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation

Protein Sequence

10 MGRKLDPTKE 20 KRGPGRKARK 30 QKGAETELVR 40 FLPAAGDENS 50 KRLSSRARKR 60 AAKRRLGSAE 70 VRETNKSPGA 80 RPLPGKLPKG 90 AVQTPSKKGA 100 LSLFNAAQGK 110 KRPASAYSSE 120 EEGEEEDSEE 130 GGVVNEGDLW 140 GSEDSDADMV 150 DDYGANSSSE 160 DEEEDDSEEL 170 LPIERAARKQ 180 KAQEAVTGSQ 190 WSEEETEEEE 200 EESPESGPRE 210 DDETEGGLQI 220 NVDEEEPFVL 230 PLAGEMEQDA 240 QAPDLQRVHK 250 RIQDIVGVLR 260 DFGTQREEGR 270 SRAEYLQRLR 280 KDLATYYSYG 290 DFLLGKLMDL 300 FPLSELVEFL 310 EANEVPRPIT 320 LRTNTLKTRR 330 RDLAQALINR 340 GVNLDPLGKW 350 SKTGLVVYDS 360 SVPIGATPEY 370 LAGHYMLQGA 380 SSMLPVMALA 390 PQEHERILDM 400 CCAPGGKTSY 410 IAQLMKNTGV 420 ILANDANAER 430 LKSVVGNLHR 440 LGVTNTIISN 450 YDGRQFPKVV 460 GGFDRVLLDA 470 PCSGTGIISK 480 DPAVKTNKDE 490 KDILRCAHLQ 500 KELLLSAIDS 510 VSATSKTGGY 520 LVYCTCSITV 530 EENEWVVDYA 540 LKKRNVRLVP 550 TGLDFGQEGF 560 TRFRERRFHP 570 TLRSTRRFYP 580 HTHNMDGFFI 590 AKFKKFSNSI 600 PQSQTGNSAT 610 STPTNPDLPS 620 PKGEVTPKPE 630 RSSQPAKKAR 640 VAVQAKQRLQ 650 KRQLPKKASF 660 QKQNGVSKGT 670 GSELSTVSSV 680 TKVQPSSKLQ 690 DSKQPAEKAV 700 VVREPKVAGR 710 LKQSPKLQSS 720 KKVAFPKQCV 730 PPKGMDPEIP 740 PVPSLSKTQD 750 AFKPEDCNQP 760 LGNTTTGAEK 770 VKQQLPEQSF 780 KKTAFQKQNG 790 TPKGPKTPTM 800 SPRSSSRPPP 810 AKRRKSQSRG 820 SSQPLPSSVD G

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity
Biological Process GO:0000470 maturation of LSU-rRNA
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:1901796 regulation of signal transduction by p53 class mediator
Biological Process GO:0000027 ribosomal large subunit assembly
Biological Process GO:0070475 rRNA base methylation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.