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Overview

Uniprot ID	F1SLS9
Protein Name	Condensin complex subunit 1
Gene Name	NCAPD2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
155	KGRKARAKSAHGFDW
215	NPTISHQKNRPTREA

Function

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size

Protein Sequence

10 MSPQLYEFHL 20 PLSPEELLKS 30 GGVNQYVVQE 40 VLSIRHLPSH 50 LKAFQAAFRA 60 QGPLAMLEHF 70 DTIYSILHHF 80 RSIDPGLKED 90 TLEFLIKVVS 100 RHSQELPTIL 110 DDAALSVSDR 120 SAHLNALKMN 130 CYALIRLLES 140 FETMTSQTSL 150 MDLDLSGKGR 160 KARAKSAHGF 170 DWEEERQPIL 180 QLLTQLLQLD 190 IRHLWNHSII 200 EEEFISLVTG 210 CCYRLLENPT 220 ISHQKNRPTR 230 EAITCLLGVA 240 LTRYNHMLSA 250 TVKIIQMLQH 260 FEHLASVLVA 270 AVSLWATDYG 280 MKSIVGEIVR 290 EIGQKCPQEL 300 SRDPSGAKGF 310 ATFLTELAER 320 VPAILMSSIC 330 ILLDHLDGEN 340 YMMRNAVLAA 350 MAEMVLQVLN 360 GDQLEAAARD 370 TRDQFLDTLQ 380 AHGHDVNSFV 390 RSRVLQLFTR 400 IVQQKALPLT 410 RFQAVVALAV 420 GRLADKSVLV 430 CKNAIQLLAS 440 FLANNPFSCK 450 LSDTDLAGPL 460 QKETQKLQEM 470 RAQRRAAAAS 480 TVLDPEDEWE 490 AMLPELKATL 500 QQLLKLPQEG 510 EGMPEEIAET 520 ETAKEVESRI 530 RQLLAKASYR 540 QAIILAREAI 550 GHFQESQPFC 560 HMDPEDSEET 570 RFLTLLGTIF 580 KGPEAPTQEK 590 TPQGAVGNLG 600 SGETGCEDQS 610 APEKHREDDE 620 LVKQEMLVQY 630 LQDAYSFSQK 640 ITEAIGIISK 650 MMYEHTTTVV 660 QEVIEFFVMV 670 FQFGVPQALF 680 GVRRMLPLIW 690 SKEPGVREAV 700 LNAYRQLYLK 710 PKGDSARAKA 720 QTLIHNLSLL 730 LVDASVGTIQ 740 CLEEILCEFV 750 QKDELKPAVT 760 QVLWERATEK 770 VPCSPLERCS 780 SVMLLGMMAR 790 GKPEIVGSNL 800 DTLVSIGLDE 810 KFPPDYRLAQ 820 QVCHAITNIS 830 DRRKPSLGKR 840 HPPFRLPQEH 850 CLFERLREMV 860 TKGIVHPDPL 870 WIPFKEAAVT 880 LIYQLAEGPE 890 AICAQMLQGC 900 AKQALEKLEE 910 KSPPQEAPKD 920 TPMLPTFLLM 930 NLLSLAGDVA 940 LQQLVHLEQA 950 VSGELCRRRV 960 LQEEQEHKAK 970 DPKEKDASSE 980 ATMEEEMGLV 990 GATADDTEAE 1000 LIRGICELEL 1010 LDGKQTLAAF 1020 VPLLLKVCNN 1030 PGLYSNPELC 1040 AAASLALGKF 1050 CMISATFCDS 1060 QLRLLFTMLE 1070 KSSLPIVRSN 1080 LMIATGDLAI 1090 RFPNLVDPWT 1100 PHLYARLRDP 1110 AQQVRKTAGL 1120 VMTHLILKDM 1130 VKVKGQVSEM 1140 AVLLIDPAPQ 1150 IAALAKNFFN 1160 ELSHKGNAIY 1170 NLLPDIISRL 1180 SAPEGGVEEE 1190 PFHTIMKQLL 1200 SYITKDKQTE 1210 SLVEKLCQRF 1220 RTARTERQYR 1230 DLAYCVSQLP 1240 LTERGLRKML 1250 DNFDCFGDKL 1260 SDESIFSAFL 1270 SVVGKLRRGA 1280 KPEGKAVIDE 1290 FEQKLRACHT 1300 RGLDAIEEFE 1310 MGQGGSQRAP 1320 SAKKLPAVSR 1330 HRHLASAASD 1340 DDFVTPEPRR 1350 TTRRHPNTQQ 1360 QVSKKKLRIV 1370 FSSDESSEEE 1380 LSAEMMEDET 1390 PKKTTPIRRA SAHRQRS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000779	condensed chromosome, centromeric region
Cellular Component	GO:0000796	condensin complex
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0000228	nuclear chromosome
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0042393	histone binding
Biological Process	GO:0051301	cell division
Biological Process	GO:0010032	meiotic chromosome condensation
Biological Process	GO:0007076	mitotic chromosome condensation
Biological Process	GO:1905821	positive regulation of chromosome condensation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.