Search Results

Overview

Uniprot IDF1SM86
Protein NameProtein 4.1
Gene NameEPB41L3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
269 RAAKRLWKVCVEHHT
289 LPEAPPKKFLTLGSK

Function

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase

Protein Sequence

10 MQCKVILLDG 20 SEYTCDVEKR 30 SRGQVLFDKV 40 CEHLNLLEKD 50 YFGLTYRDAE 60 NQKNWLDPAK 70 EIKKQIRSGA 80 WHFSFNVKFY 90 PPDPAQLSED 100 ITRYYLCLQL 110 RDDIVSGRLP 120 CSFVTLALLG 130 SYTVQSELGD 140 YDPDECGSDY 150 VSEFRFAPNH 160 TKELEDKVIE 170 LHKSHRGMTP 180 AEAEMHFLEN 190 AKKLSMYGVD 200 LHHAKDSEGV 210 DIMLGVCASG 220 LLIYRDRLRI 230 NRFAWPKVLK 240 ISYKRNNFYI 250 KIRPGEFEQF 260 ESTIGFKLPN 270 HRAAKRLWKV 280 CVEHHTFFRL 290 LLPEAPPKKF 300 LTLGSKFRYS 310 GRTQAQTRRA 320 SALIDRPAPY 330 FERSSSKRYT 340 MSRSLDGASV 350 NENHEMYMKD 360 SVSAAEVGTG 370 QYATTKGISQ 380 TNLITTVTPE 390 KKAEEERDEE 400 EERRKKAEEA 410 TPVATVRHEG 420 KSPGLGTDSC 430 SLSPPSAHRA 440 PASPTELRRR 450 CKEKERPPPG 460 AEPSRDPGHL 470 CGEPTSDSDG 480 QGKPRLRDQD 490 VAFSYKQQAG 500 RGATLFSFSL 510 QLPASFPSLL 520 DDDGYLSFPS 530 LSETSLLPQS 540 LQHYLPIRSP 550 SLVPCFLFIF 560 FFLLSASFSV 570 PYALTLSFPL 580 ALCLCYLEPK 590 AASLSASLDN 600 DPSDSSEEET 610 DSERTDTAAD 620 GETTATEEML 630 HGDELDKTQD 640 DLMKHQTNIS 650 ELKRTFLETS 660 TDTAVTNEWE 670 KRLSTSPVRL 680 AARPEEAPMI 690 EPLVPEETKQ 700 SSGEKLMDGS 710 EIFSLLESAR 720 KPTEFIGGVT 730 STSQSWVQKT 740 ETKTESSETE 750 TETTQRPQPL 760 STETVVQETV 770 LVEERHVMSV 780 HASGDASSTA 790 GDGVDAAAQA 800 ASAEASGVKG 810 KEGSALTEGA 820 KEDKGEVADR 830 AVLEQEVMAT 840 ASQEPEEERL 850 SAAIHVSETL 860 EQKPHFESST 870 VKTETISFGS 880 VSPGGIKLEI 890 STKEVPVVHT 900 ETKTITYESS 910 QVDLGADLEP 920 GVLMSAQTIT 930 SETTSTTTTT 940 HITRTVKGGI 950 SETRIEKRIV 960 ITGDADIDHD QVVC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005856 cytoskeleton
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0030866 cortical actin cytoskeleton organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.