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Overview

Uniprot IDF1SMB2
Protein NameAcetyltransferase component of pyruvate dehydrogenase complex
Gene NameDLAT
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
283 PATPAGPKGRLFVSP
293 LFVSPLAKKLASEKG
307 GIDLTQIKGTGPDGR
318 PDGRIIKKDIDSFVP
404 KMLEGRSKISVNDFI

Function

The pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3);. Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA formation

Protein Sequence

10 MWRVCARRAQ 20 NAAPRAGFGA 30 RWTALREEPG 40 APCAAPRAGS 50 VPARCSSTTR 60 GYGRSRALCG 70 WSASSWATPQ 80 NRILLQLWGS 90 PNRRWYSLPP 100 HQKVPLPSLS 110 PTMQAGTIAR 120 WEKKEGDKIN 130 EGELIAEVET 140 DKATVGFESL 150 EECYMAKILV 160 AEGTRDVPVG 170 AIICITVEKP 180 EDIEAFKNYT 190 LDSSAAPAPQ 200 AAPAPTPAAA 210 APAPTPSAQA 220 PGSSYPTHMQ 230 VVLPALSPTM 240 TMGTVQRWEK 250 KVGEKLSEGD 260 LLAEIETDKA 270 TIAPQPVAPT 280 PAATRPATPA 290 GPKGRLFVSP 300 LAKKLASEKG 310 IDLTQIKGTG 320 PDGRIIKKDI 330 DSFVPTKAAP 340 PPAAAVPPPS 350 PGVAPVPTGV 360 FTDIPISNIR 370 RVIAQRLMQS 380 KQTIPHYYLS 390 VDVNMGEVLL 400 VRKELNKMLE 410 GRSKISVNDF 420 IIKASALACL 430 KVPEANSSWL 440 DTVIRQNHVV 450 DISVAVSTPA 460 GLITPIVFNA 470 HIKGLETIAN 480 DVVSLATKAR 490 EGKLQPHEFQ 500 GGTFTISNLG 510 MFGIKNFSAI 520 INPPQACILA 530 VGASEDRLFP 540 ADNEKGFDVA 550 SMMSVTLSCD 560 HRVVDGAVGA 570 QWLAEFRKYL EKPITMLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0045254 pyruvate dehydrogenase complex
Molecular Function GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0006086 pyruvate decarboxylation to acetyl-CoA

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.