Search Results

Overview

Uniprot IDF1SMG3
Protein NameNAD(P) transhydrogenase, mitochondrial
Gene NameNNT
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1071 MLLGDAKKTCDALQA
1079 TCDALQAKVRESYQK
324 TALIPGKKAPVLFNK
451 IPQGAPVKQKTVAEL
70 KEIFQNEKRVALSPA

Function

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland

Protein Sequence

10 MANLLKTVVT 20 GCSCPFRSSW 30 GSCKVLPGKK 40 DFLRTFHTHQ 50 ALWCKAPVKP 60 GIPYKQLTVG 70 VPKEIFQNEK 80 RVALSPAGVQ 90 ALVKQGFNVV 100 VESGAGEASK 110 FSDDHYRAAG 120 AQIQGVKEVL 130 ASDLVVKVRA 140 PMLNPTLGVH 150 EADLLKTSAT 160 LISFIYPAQN 170 PDLLNKLSKR 180 KTTVLAMDQV 190 PRVTIAQGYD 200 ALSSMANIAG 210 YKAVVLAANH 220 FGRFFTGQIT 230 AAGKVPPAKI 240 LIVGGGVAGL 250 ASAGAAKSMG 260 AIVRGFDTRA 270 AALEQFKSLG 280 AEPLEVDLKE 290 SGEGQGGYAK 300 EMSKEFIEAE 310 MKLFAQQCKE 320 VDILISTALI 330 PGKKAPVLFN 340 KEMIESMKEG 350 SVVVDLAAEA 360 GGNFETTKPG 370 ELYVHKGVTH 380 IGYTDLPSRM 390 ATQASTLYSN 400 NITKLLKAIS 410 PDKDNFYFEV 420 KDDFDFGTMG 430 HVIRGTVVMK 440 DGEVIFPAPT 450 PKNIPQGAPV 460 KQKTVAELEA 470 EKAATITPFR 480 KTMTSASVYT 490 AGLTGILGLG 500 LAAPNLAFSQ 510 MVTTFGLAGI 520 VGYHTVWGVT 530 PALHSPLMSV 540 TNAISGLTAV 550 GGLVLMGGHL 560 YPSTTSQGLA 570 ALATFISSVN 580 IAGGFLVTQR 590 MLDMFKRPTD 600 PPEYNYLYLL 610 PAGTFVGGYL 620 AALYSGYNIE 630 QIMYLGSGLC 640 CVGALAGLST 650 QGTARLGNAL 660 GMIGVAGGLA 670 ATLGGLKPCP 680 ELLAQMSGAM 690 ALGGTIGLTI 700 AKRIQISDLP 710 QLVAAFHSLV 720 GLAAVLTCIA 730 EYIVEYPHFA 740 TDAAANLTKI 750 VAYLGTYIGG 760 VTFSGSLIAY 770 GKLQGILKSA 780 PLLLPGRHLL 790 NAGLLAASVG 800 GIIPFMVDPS 810 FTTGITCLGS 820 VSALSAVMGV 830 TLTAAIGGAD 840 MPVVITVLNS 850 YSGWALCAEG 860 FLLNNNLLTI 870 VGALIGSSGA 880 ILSYIMCVAM 890 NRSLANVILG 900 GYGTTSTAGG 910 KPMEISGTHT 920 EINLDNAIDM 930 IREANSIIIT 940 PGYGLCAAKA 950 QYPIADLVKM 960 LSEQGKKVRF 970 GIHPVAGRMP 980 GQLNVLLAEA 990 GVPYDIVLEM 1000 DEINHDFPDT 1010 DLVLVIGAND 1020 TVNSAAQEDP 1030 NSIIAGMPVL 1040 EVWKSKQVIV 1050 MKRSLGVGYA 1060 AVDNPIFYKP 1070 NTAMLLGDAK 1080 KTCDALQAKV RESYQK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Molecular Function GO:0016491 oxidoreductase activity
Molecular Function GO:0008750 proton-translocating NAD(P)+ transhydrogenase activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.