Search Results
Overview
| Uniprot ID | F1SMG8 |
|---|---|
| Protein Name | Hydroxymethylglutaryl-CoA synthase |
| Gene Name | HMGCS1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 329 | PYCKLVQKSLARMLL |
| 386 | SSELFNQKTKASLLV |
| 465 | IASLCDLKSRLDSRT |
| 554 | EHIPSPAKKVPRLPA |
Function
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA
Protein Sequence
10
MGSRERRMGS
20
RAKLRRPTAA
30
GPRRDRGPLM
40
WAVPGGGNRV
50
TDLETAVLYP
60
SHSFFTMPGS
70
LPLNAEACWP
80
KDVGIVALEI
90
YFPSQYVDQA
100
ELEKYDGVAA
110
GRYTIGLGQA
120
KMGFCTDRED
130
INSLCMTVVQ
140
NLMERNSLSY
150
DCIGRLEVGT
160
ETIIDKSKSV
170
KTNLMQLFEE
180
SGNTDIEGID
190
TINACYGGTA
200
AVFNAVNWIE
210
SSSWDGRYAL
220
VVAGDIAVYA
230
AGNARPTGGV
240
GAIALLIGPN
250
APLIFERGLR
260
GTHMQHAYDF
270
YKPDMLSEYP
280
IVDGKLSIEC
290
YLSALDRCYS
300
VYRKKIHARW
310
QKEGNDKDFT
320
LNDFGFMVFH
330
SPYCKLVQKS
340
LARMLLNDFL
350
NDQNRDKNSI
360
YSGLEAFGDV
370
KLEDTYFDRD
380
VEKAFMKASS
390
ELFNQKTKAS
400
LLVSNQNGNM
410
YTSSLYGCLA
420
SVLAQYSPQE
430
LAGKRIGMFS
440
YGSGLAATLY
450
SLKVTQDATP
460
GSALDKIIAS
470
LCDLKSRLDS
480
RTCVAPDVFT
490
ENMKLREDTH
500
HLVNYIPQSS
510
IDSLFEGTWY
520
LVRVDEKHRR
530
TYARRPSRNE
540
STLDEGVELV
550
HSSTATEHIP
560
SPAKKVPRLP
570
ATAAEPEVAV
ISNGEH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0006084 | acetyl-CoA metabolic process |
| Biological Process | GO:0033489 | cholesterol biosynthetic process via desmosterol |
| Biological Process | GO:0033490 | cholesterol biosynthetic process via lathosterol |
| Biological Process | GO:0010142 | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0033386 | geranylgeranyl diphosphate biosynthetic process |
| Biological Process | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0036197 | zymosterol biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.