Search Results
Overview
| Uniprot ID | F1SML7 |
|---|---|
| Protein Name | Inosine-5'-monophosphate dehydrogenase |
| Gene Name | IMPDH1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 299 | LASKDSHKQLLCGAA |
| 350 | MVHYIKQKYPHLQVI |
| 495 | FSEGDKVKIAQGVSG |
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors
Protein Sequence
10
MEEPRAPPAG
20
SGQLPPPLQG
30
GGAADVPECG
40
ARQHPGHETA
50
AQRYSARLLQ
60
AGYEPESMAD
70
YLISGGTGYV
80
PEDGLTAQQL
90
FANADGLTYN
100
DFLILPGFID
110
FTADEVDLTS
120
ALTRKITLKT
130
PLISSPMDTV
140
TEADMAIAMA
150
LMGGIGFIHH
160
NCTPEFQANE
170
VRKVKKFEQG
180
FITDPVVLSP
190
SHTVGDVLEA
200
KMRHGFSGIP
210
ITETGTMGSK
220
LVGIVTSRDI
230
DFLAEKDHTT
240
LLSEVMTPRN
250
ELVVAPAGVT
260
LKEANEILQR
270
SKKGKLPIVN
280
DRDELVAIIA
290
RTDLKKNRDY
300
PLASKDSHKQ
310
LLCGAAVGTR
320
EDDKYRLDLL
330
TQAGADVIVL
340
DSSQGNSVYQ
350
IAMVHYIKQK
360
YPHLQVIGGN
370
VVTAAQAKNL
380
IDAGVDGLRV
390
GMGCGSICIT
400
QEVMACGRPQ
410
GTAVYKVAEY
420
ARRFGVPVIA
430
DGGIQTVGHV
440
VKALALGAST
450
VMMGSLLAAT
460
TEAPGEYFFS
470
DGVRLKKYRG
480
MGSLDAMEKS
490
SSSQKRYFSE
500
GDKVKIAQGV
510
SGSIQDKGSI
520
QKFVPYLIAG
530
IQHGCQDIGA
540
RSLSVLRSMM
550
YSGELKFEKR
560
TMSAQIEGGV
570
HGLHSYEKRL
Y
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003938 | IMP dehydrogenase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0097294 | 'de novo' XMP biosynthetic process |
| Biological Process | GO:0006177 | GMP biosynthetic process |
| Biological Process | GO:0006183 | GTP biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.