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Overview

Uniprot IDF1SMW9
Protein Name26S proteasome non-ATPase regulatory subunit 1
Gene NamePSMD1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
109 KCIDHYTKQCVENAD
145 QRCLDDHKYKQAIGI
147 CLDDHKYKQAIGIAL
309 TGSVLVGKTPEASPE
573 IESLCRDKDPILRRS
714 QFRQLYSKVINDKHD
802 KMPKVQYKSNCKPST

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair

Protein Sequence

10 LCLIAGIISL 20 LDEEEPQLKE 30 FALHKLNAVV 40 NDFWAEISES 50 VDKIEVLYED 60 EGFRSRQFAA 70 LVASKVFYHL 80 GAFEESLNYA 90 LGAGDLFNVN 100 DNSEYVETII 110 AKCIDHYTKQ 120 CVENADLPEG 130 EKKPIDQRLE 140 GIVNKMFQRC 150 LDDHKYKQAI 160 GIALETRRLD 170 VFEKTILESN 180 DVPGMLAYSL 190 KLCMSLMQNK 200 QFRNKVLRVL 210 VKIYMNLEKP 220 DFINVCQCLI 230 FLDDPQAVSD 240 ILEKLVKEDN 250 LLMAYQICFD 260 LYESASQQFL 270 SSVIQNLRTV 280 GTPIASVPGS 290 TNTGTVPGSE 300 KDSESMETEE 310 KTGSVLVGKT 320 PEASPEPKDQ 330 TLKMIKILSG 340 EMAIELHLQF 350 LIRNNNTDLM 360 ILKNTKDAVR 370 NSVCHTATVI 380 ANSFMHCGTT 390 SDQFLRDNLE 400 WLARATNWAK 410 FTATASLGVI 420 HKGHEKEALQ 430 LMATYLPKDT 440 SPGSAYQEGG 450 GLYALGLIHA 460 NHGGDIIDYL 470 LNQLKNASND 480 IVRHGGSLGL 490 GLAAMGTARQ 500 DVYDLLKTNL 510 YQDDAVTGEA 520 AGLALGLVML 530 GSKNAQAIED 540 MVGYAQETQH 550 EKILRGLAVG 560 IALVMYGRME 570 EADALIESLC 580 RDKDPILRRS 590 GMYTVAMAYC 600 GSGNNKAIRR 610 LLHVAVSDVN 620 DDVRRAAVES 630 LGFILFRTPE 640 QCPSVVSLLS 650 ESYNPHVRYG 660 AAMALGICCA 670 GTGNKEAINL 680 LEPMTNDPVN 690 YVRQGALIAS 700 ALIMIQQTEI 710 TCPKVNQFRQ 720 LYSKVINDKH 730 DDVMAKFGAI 740 LAQGILDAGG 750 HNVTISLQSR 760 TGHTHMPSVV 770 GVLVFTQFWF 780 WFPLSHFLSL 790 AYTPTCVIGL 800 NKDLKMPKVQ 810 YKSNCKPSTF 820 AYPAPLEVPK 830 EKEKEKVSTA 840 VLSITAKAKK 850 KEKEKEKKEE 860 EKMEVDEAEK 870 KEEKEKKKEP 880 EPNFQLLDNP 890 ARVMPAQLKV 900 LSMPETCRYQ 910 PFKPLSIGGI 920 IILKDTSEDI 930 EELVEPVAAH 940 GPKIEEEEQE 950 PEPPEPFEYI DD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Cellular Component GO:0008540 proteasome regulatory particle, base subcomplex
Cellular Component GO:0034515 proteasome storage granule
Molecular Function GO:0030234 enzyme regulator activity
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0042176 regulation of protein catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.