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Overview

Uniprot IDF1SNE9
Protein NameCoatomer subunit gamma
Gene NameCOPG2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
175 KISYDVVKRWVNEAQ
815 QPCERSDKVPENKNS

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors

Protein Sequence

10 MIKKFDKKDE 20 ESGSGSNPFR 30 HLEKSAVLQE 40 ARIFNETPIN 50 PRRCLHILTK 60 ILYLLNQGEY 70 FGTTEATEAF 80 FAMTRLFQSN 90 DQTLRRMCYL 100 TIKEMATISE 110 DVIIVTSSLT 120 KDMTGKEDVY 130 RGPAIRALCR 140 ITDGTMLQAI 150 ERYMKQAIVD 160 KVSSVSSSAL 170 VSSLHMMKIS 180 YDVVKRWVNE 190 AQEAASSDNI 200 MVQYHALGVL 210 YHLKKNDRLA 220 VSKMLNKFTK 230 CGLKSQFAYC 240 MLIRIASRLL 250 KENEEGHESP 260 VFDFIESCLR 270 NKHEMVIYEA 280 ASAIIHLPNC 290 SARELAPAVS 300 VLQLFCSSPK 310 PALRYAAVRT 320 LNKVAMKHPS 330 AVTACNLDLE 340 NLITDSNRSI 350 ATLAITTLLK 360 TGSESSVDRL 370 MKQISSFVSE 380 ISDEFKVVVV 390 QAISALCQKY 400 PRKHSVMMTF 410 LSNMLRDDGG 420 FEYKRAIVDC 430 IINIVEENPE 440 SKEAGLAHLC 450 EFIEDCEHTV 460 LATKILHLLG 470 KEGPRTPVPS 480 KYIRFIFNRV 490 VLENEAVRAA 500 AVSALAKFGA 510 QNENLLPSIL 520 VLLQRCMMDT 530 DDEVRDRATF 540 YLNVLQQRQM 550 ALNATYIFNG 560 LTVSVPGMEK 570 ALHQYTLEPS 580 EKPFDMKSIP 590 LAMAPVFEQK 600 SEITLVATKP 610 EKLAPSRQDI 620 FQEQLAAIPE 630 FMNLGPLFKS 640 SEPVQLTEAE 650 TEYFVRCVKH 660 MFTNHVVFQF 670 DCTNTLNDQL 680 LEKVTVQVEP 690 SDSYEVLCCI 700 PAASLPYNQP 710 GICYTLVRLP 720 DDDSIAAAGT 730 FSCTMKFTVR 740 DCDPDTGVPA 750 EEGYDDEYVL 760 EDLEVTVSDH 770 IQKVLKPNFA 780 AAWEEVGDTF 790 EKEETFALSS 800 TKTLEEAVSN 810 IITFLGMQPC 820 ERSDKVPENK 830 NSHALYLAGV 840 YRGGCDLLVR 850 SRLALADGVT 860 MQVTVRSKEG 870 TPVDVILASV G

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030126 COPI vesicle coat
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
Cellular Component GO:0000139 Golgi membrane
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0006891 intra-Golgi vesicle-mediated transport
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0072384 organelle transport along microtubule
Biological Process GO:0009306 protein secretion

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.