Search Results
Overview
| Uniprot ID | F1SNL7 |
|---|---|
| Protein Name | Cytosolic non-specific dipeptidase |
| Gene Name | CNDP2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 373 | AELHSPNKFKVYMGH |
Function
Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides. Mediates threonyl dipeptide catabolism in a tissue-specific way. Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism. Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis. Plays a role in the regulation of cell cycle arrest and apoptosis
Protein Sequence
10
MPALAALFKY
20
IDENQDRYIK
30
KLAEWVAIQS
40
VSAWPEKRGE
50
IRKMMEVAAA
60
DITQLGGSVE
70
LVDIGNQKLP
80
DGSEIPLPPI
90
LLGKLGSDPQ
100
KKTVCVYGHL
110
DVQPAALEDG
120
WDSEPFTLVE
130
RDGKLYGRGA
140
TDDKGPVAGW
150
VNALEAFQKT
160
NQEVPVNIRF
170
CLEGMEESGS
180
EGLDALIFAQ
190
KDQFFKDVDF
200
VCISDNYWLG
210
KNKPCVTYGL
220
RGICYFFIEV
230
ECSNRDLHSG
240
VYGGSVHEAM
250
TDLITLMGSL
260
MDRKGKILIP
270
GINEAVAPLT
280
EEELALYDQI
290
DFDLAEYSKD
300
VGAETLLHDC
310
KKDILMHRWR
320
YPSLSLHGIE
330
GAFSGSGAKT
340
VIPRKVIGKF
350
SIRLVPDMTP
360
EVVSEQVISY
370
LTKKFAELHS
380
PNKFKVYMGH
390
GGKPWVSDFN
400
HPHYMAGRRA
410
LQTVFGVEPD
420
LTREGGSIPV
430
TLTFQEATGK
440
NVMLLPMGSA
450
DDGAHSQNEK
460
LNRHNYIEGT
470
KMMAAYLYEV
SQLKN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0004180 | carboxypeptidase activity |
| Molecular Function | GO:0016805 | dipeptidase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0070573 | metallodipeptidase activity |
| Biological Process | GO:0019184 | nonribosomal peptide biosynthetic process |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.