Search Results
Overview
| Uniprot ID | F1SNW8 |
|---|---|
| Protein Name | Hexokinase-2 |
| Gene Name | HK2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 488 | REQLLEVKRRMKVEM |
Function
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis
Protein Sequence
10
MIASHLLAYF
20
FTELNHDQVQ
30
KVDQYLYHMR
40
LSDETLLEIA
50
KRFRKEMEKG
60
LGATTHPTAS
70
VKMLPTFVRS
80
TPDGTEHGEF
90
LALDLGGTNF
100
RVLWVRVTDN
110
GLQKVEMENQ
120
IYAIPEDIMR
130
GSGTQLFDHI
140
AECLANFMDK
150
LQIKDKKLPL
160
GFTFSFPCIQ
170
TKLDESFLVS
180
WTKGFKSSGV
190
EGKDVVTLIR
200
KAIQRRGDFD
210
IDIVAVVNDT
220
VGTMMTCGYD
230
DQNCEIGLIV
240
GTGSNACYME
250
EMRHIDMVEG
260
DEGRMCINME
270
WGAFGDDGAL
280
DDIRTEFDQE
290
IDMGSLNPGK
300
QLFEKMISGL
310
YMGELVRLIL
320
VKMAKEELLF
330
GGKLSPELLA
340
TGHFETKDVS
350
DIEGEKDGIR
360
KAREVLVRLG
370
LDPTQEDCVA
380
THRVCQIVST
390
RSASLCAATL
400
AAVLRRIKEN
410
KGEERLRSTI
420
GVDGSVYKKH
430
PHFAKRLHKT
440
LRRLVPDCDI
450
RFLRSEDGSG
460
KGAAMVTAVA
470
YRLADQHRAR
480
QKTLEPLKLS
490
REQLLEVKRR
500
MKVEMERGLS
510
KETHAIAPVK
520
MLPTYVCATP
530
DGTEKGDFLA
540
LDLGGTNFRV
550
LLVRVRNGKR
560
RGVEMHNKIY
570
SIPQEVMHGT
580
GDELFDHIVQ
590
CIADFLEYMG
600
VKGVSLPLGF
610
TFSFPCQQNS
620
LDESILLKWT
630
KGFKASGCEG
640
EDVVTLLKEA
650
IHRREEFDLD
660
VVAVVNDTVG
670
TMMTCGYEDP
680
HCEVGLIVGT
690
GSNACYMEEM
700
RNVELVEGEE
710
GRMCVNMEWG
720
AFGDNGCLDD
730
LRTEFDAAVD
740
ELSLNAGKQR
750
FEKMISGMYL
760
GEIVRNILID
770
FTKRGLLFRG
780
RISERLKTRG
790
IFETKFLSQI
800
ESDCLALLQV
810
RAILHHLGLE
820
STCDDSIIVK
830
EVCTVVARRA
840
AQLCGAGMAA
850
VVDKIRENRG
860
LDTLKVTVGV
870
DGTLYKLHPH
880
FAKIMHETVK
890
DLAPKCDVSF
900
LESEDGSGKG
910
AALITAVACR
IREAGQR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005536 | D-glucose binding |
| Molecular Function | GO:0008865 | fructokinase activity |
| Molecular Function | GO:0004340 | glucokinase activity |
| Biological Process | GO:0061621 | canonical glycolysis |
| Biological Process | GO:0072655 | establishment of protein localization to mitochondrion |
| Biological Process | GO:0051156 | glucose 6-phosphate metabolic process |
| Biological Process | GO:0006006 | glucose metabolic process |
| Biological Process | GO:0006096 | glycolytic process |
| Biological Process | GO:0001678 | intracellular glucose homeostasis |
| Biological Process | GO:0072656 | maintenance of protein location in mitochondrion |
| Biological Process | GO:0035795 | negative regulation of mitochondrial membrane permeability |
| Biological Process | GO:2000378 | negative regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:1905091 | positive regulation of type 2 mitophagy |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.