Search Results

Overview

Uniprot IDF1SPG9
Protein NameExtended synaptotagmin-1
Gene NameESYT1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
172 TRVELGEKPLRILGV
180 PLRILGVKVHPGQRK
214 EVKKYFCKAGVKGMQ
332 SSKDKYVKGLIEGKS
338 VKGLIEGKSDPYALV
476 RAQDLPLKKGNKEPN
632 RFLGGLVKGKSDPYV
640 GKSDPYVKLKLAGRS

Function

Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport

Protein Sequence

10 MERSPGDRSS 20 PVDQPYPDQS 30 SGNQPAGPGA 40 AGEALAVLTS 50 FGRRLLVLVP 60 VYLAGAMGLS 70 VGFVLFGLAL 80 YLGWRRVREE 90 KERSLRVAQQ 100 LLEDEERLTA 110 KTLYMSQREL 120 PAWVSFPDVE 130 KAEWLNKIVA 140 QVWPFLGQYM 150 EKLLAETVAP 160 AVRGSNPHLQ 170 TFTFTRVELG 180 EKPLRILGVK 190 VHPGQRKEQI 200 LLDLNISYVG 210 DVQIDVEVKK 220 YFCKAGVKGM 230 QLHGVLRVIL 240 EPLIGDLPIV 250 GAVSMFFIRR 260 PTLDINWTGM 270 TNLLDIPGLS 280 SLSDTMIMDS 290 IAAFLVLPNR 300 LLVPLVPDLQ 310 DVAQLRSPLP 320 RGIIRVHLLA 330 ARGLSSKDKY 340 VKGLIEGKSD 350 PYALVRVGTQ 360 AFCSRVIDEE 370 LNPQWGETYE 380 VMVHEVPGQE 390 IEVEVFDKDP 400 DKDDFLGRMK 410 LDVGKVLQAA 420 VMDEWFPLQG 430 GQGQVHLRLE 440 WLSLLPDAEK 450 LEQILQWNRG 460 VSSRPEPPSA 470 AILVVYLDRA 480 QDLPLKKGNK 490 EPNPMVQLSV 500 QDVTQESKAV 510 YSTNSPVWEE 520 AFRFFLQDPR 530 SQELDVQVKD 540 DSRALTLGAL 550 TLPLARLLTA 560 PELTLDQWFQ 570 LSKVRFPAGP 580 GTPEAWDLDN 590 ESPQTGSSVD 600 TPPRPSHTTP 610 DSNFGTENVL 620 RIHVLEAQDL 630 IAKDRFLGGL 640 VKGKSDPYVK 650 LKLAGRSFRS 660 RVIREDLNPH 670 WNEVFEVIVT 680 SIPGQELEAE 690 VFDKDLDKDD 700 FLGRCKVSLT 710 TVLNSGFLDE 720 WLTLEDVPSG 730 RLHLRLERLT 740 PRPTAAELEE 750 VLQVNSLIQT 760 QKSAELAAAL 770 LSVYLERAED 780 LPLRKGTKPP 790 SPYATLAVGE 800 TSHKTKTVPQ 810 TSAPIWDESA 820 SFLIRKPNIE 830 SLELQVRGEG 840 TGVLGSLSLP 850 LSELLVADRL 860 CLDRWFTLSS 870 GQGQVLLRAQ 880 LGILVSQHSG 890 VEAHSHSHSS 900 SSLSEEPELW 910 GGLPHVTSSA 920 PELRQRLTHG 930 DSPQEAPAGP 940 LGQVKLTVWY 950 YSEERKLVSM 960 VHSCRALRQN 970 GRDPPDPYVS 980 LLLLPDKNRG 990 TKRKTSQKKR 1000 TLNPEFNERF 1010 EWELPLDEAL 1020 RRKLDVSVKS 1030 SSSFMSRERE 1040 LLGKVRGQGG 1050 QGQGRVRSCQ WQGL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0008289 lipid binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0061817 endoplasmic reticulum-plasma membrane tethering
Biological Process GO:0006869 lipid transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.