Overview
| Uniprot ID | F1SPK8 |
|---|
| Protein Name | Tetraspanin |
|---|
| Gene Name | CD63 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 112 |
YVFRDKVKAEFNKDF |
| 162 |
EKILLSPKRVPDSCC |
| 193 |
HNEGCVEKIGSWLRS |
Function
Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli
Protein Sequence
10
MAVEGGMRCV
20
KFLLYVLLLA
30
FCACAVGLIA
40
VGIWVQLVLN
50
QTITQGATPG
60
SLLPVVIIAV
70
GAFLFLVAFV
80
GCCGTCKENY
90
CLMVTFAIFL
100
SLIMLVEVAA
110
AIAGYVFRDK
120
VKAEFNKDFQ
130
QQMQNYPKNN
140
HTALILDRMQ
150
EDFKCCGAAN
160
YTDWEKILLS
170
PKRVPDSCCV
180
NVTQHCGVNF
190
NVKEIHNEGC
200
VEKIGSWLRS
210
NVLVAAAAAL
220
GIAFVEVLGI
230
VFACCLVKSI
RSGYEVM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0031904 |
endosome lumen |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0042470 |
melanosome |
| Cellular Component |
GO:0032585 |
multivesicular body membrane |
| Cellular Component |
GO:0097487 |
multivesicular body, internal vesicle |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Biological Process |
GO:0016477 |
cell migration |
| Biological Process |
GO:0007160 |
cell-matrix adhesion |
| Biological Process |
GO:0035646 |
endosome to melanosome transport |
| Biological Process |
GO:2001046 |
positive regulation of integrin-mediated signaling pathway |
| Biological Process |
GO:0002092 |
positive regulation of receptor internalization |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:1900746 |
regulation of vascular endothelial growth factor signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.