Search Results
Overview
| Uniprot ID | F1SPN4 |
|---|---|
| Protein Name | Probable ATP-dependent RNA helicase DDX23 |
| Gene Name | DDX23 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 634 | VYIGSAGKPHERVEQ |
Function
Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA
Protein Sequence
10
MAGELADKKD
20
RDASPSKDER
30
KRSRTPDRER
40
DRDRDRKSSP
50
SKDRKRHRSR
60
DRRRGGSRSR
70
SRSRSKSTER
80
DRRHKERERD
90
KERDRNKKDR
100
DRDKDGHRRD
110
KDRKRSSLSP
120
GRGKDFKSRK
130
DRDFKKDEED
140
EHGDKKPKAQ
150
PLSLEELLAK
160
KKAEEEAEAK
170
PKFLSKAERE
180
AEALKRRQQE
190
VEERQRMLEE
200
ERKKRKQFQD
210
LGRKMLEDPQ
220
ERERRERRER
230
MERETNGNED
240
EEGRQKIREE
250
KDKSKELHAI
260
KERYLGGIKK
270
RRRTRHLNDR
280
KFVFEWDASE
290
DTSIDYNPLY
300
KERHQVQLLG
310
RGFIAGIDLK
320
QQKREQSRFY
330
GDLMEKRRTL
340
EEKEQEEARL
350
RKLRKKEAKQ
360
RWDDRHWSQK
370
KLDEMTDRDW
380
RIFREDYSIT
390
TKGGKIPNPI
400
RSWKDSSLPP
410
HILEVIDKCG
420
YKEPTPIQRQ
430
AIPIGLQNRD
440
IIGVAETGSG
450
KTAAFLIPLL
460
VWITTLPKID
470
RIEESDQGPY
480
AIILAPTREL
490
AQQIEEETIK
500
FGKPLGIRTV
510
AVIGGISRED
520
QGFRLRMGCE
530
IVIATPGRLI
540
DVLENRYLVL
550
SRCTYVVLDE
560
ADRMIDMGFE
570
PDVQKILEHM
580
PVSNQKPDTD
590
EAEDPEKMLA
600
NFESGKHKYR
610
QTVMFTATMP
620
PAVERLARSY
630
LRRPAVVYIG
640
SAGKPHERVE
650
QKVFLMSESE
660
KRKKLLAILE
670
QGFDPPIIIF
680
VNQKKGCDVL
690
AKSLEKMGYN
700
ACTLHGGKGQ
710
EQREFALSNL
720
KAGAKDILVA
730
TDVAGRGIDI
740
QDVSMVVNYD
750
MAKNIEDYIH
760
RIGRTGRAGK
770
SGVAITFLTK
780
EDSAVFYELK
790
QAILESPVSS
800
CPPELANHPD
810
AQHKPGTILT
820
KKRREETIFA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Cellular Component | GO:0005682 | U5 snRNP |
| Cellular Component | GO:0005891 | voltage-gated calcium channel complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0008331 | high voltage-gated calcium channel activity |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0003676 | nucleic acid binding |
| Molecular Function | GO:0003724 | RNA helicase activity |
| Biological Process | GO:0006816 | calcium ion transport |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0062176 | R-loop processing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.