Overview
| Uniprot ID | F1SQA9 |
|---|
| Protein Name | Protein SEC13 homolog |
|---|
| Gene Name | SEC13 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 165 |
QKPNYIKKFASGGCD |
| 22 |
CSSDRSVKIFDVRNG |
Function
As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex
Protein Sequence
10
HDAQMDYYGT
20
RLATCSSDRS
30
VKIFDVRNGG
40
QILIADLRGH
50
EGPVWQVAWA
60
HPMYGNILAS
70
CSYDRKVIIW
80
KEENGTWEKT
90
HEHTGHDSSV
100
NSVCWAPHDY
110
GLILACGSSD
120
GAISLLTYTG
130
LGQWEVKKIN
140
NAHTIGCNAV
150
SWAPAVVPGS
160
LIDQPSGQKP
170
NYIKKFASGG
180
CDNLIKLWKE
190
EEDGQWKEEQ
200
KLEAHSDWVR
210
DVAWAPSIGL
220
PTSTIASCSQ
230
DGRVFIWTCD
240
DASGNTWSPK
250
LLHKFNDVVW
260
HVSWSITANI
270
LAVSGGDNKV
280
TLWKESVDGQ
290
WVCISDVNKG
300
QGSVSTSITE
GQQNEQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0005643 |
nuclear pore |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0051028 |
mRNA transport |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.