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Overview

Uniprot IDF1SQH4
Protein NameDNA mismatch repair protein
Gene NameMSH2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
528 YYFRVTCKEEKVLRN
537 EKVLRNNKNFSTVDI

Function

Component of the post-replicative DNA mismatch repair system (MMR)

Protein Sequence

10 MAVQPKETLQ 20 LESAAEIGFV 30 RFFQGMPEKP 40 TTTVRLFDRG 50 DFYTAHGEDA 60 LLAAREVFKT 70 QGVVKFMGPA 80 GAKTLESVVL 90 SKMNFESFVK 100 DLLLVRQYRV 110 EVYKNRAGNK 120 ASKEHDWYLA 130 FKASPGNLSQ 140 FEDILFGNND 150 MSASIGVVGV 160 KMSTVDGQRQ 170 VGVGYVDSIQ 180 RKLGLCEFPD 190 NDQFSNLEAL 200 LIQIGPKECV 210 LPGGDTAGDM 220 GKLRQVIQRG 230 GILITERKRA 240 DFSTKDIYQD 250 LNRLLKGKKG 260 EQMNSAVLPE 270 MENQVAVSSL 280 SAVIKFLELL 290 ADDSNFGQFE 300 LTTFDFSQYM 310 KLDMAAVRAL 320 NLFQGSVEDT 330 AGSQSLAALL 340 NKCKTPQGQR 350 LVNQWIKQPL 360 MDKNRIEERL 370 NLVEAFVEDA 380 ELRQSLQEDL 390 LRRFPDLNRL 400 AKKFQRQAAN 410 LQDCYRLYQG 420 INQLPNVIQA 430 MEKYEGQHQA 440 LLLAVFVTPL 450 IDLRSDFSKF 460 QEMIETTLDM 470 DQVENHEFLV 480 KPSFDPNLSE 490 LREIMDDLEK 500 KMQSTLISAA 510 RDLGLDPGKQ 520 IKLDSSAQFG 530 YYFRVTCKEE 540 KVLRNNKNFS 550 TVDIQKNGVK 560 FTNSKLTSLN 570 EEYTKNKTEY 580 EEAQNAIVKE 590 IVNISSGYVE 600 PMQTLNDVLA 610 QLDAVVSFAH 620 VSNGAPVPYV 630 RPVILEKGQG 640 RITLKASRHA 650 CVEVQDEVAF 660 IPNDVHFEKD 670 KQMFHIITGP 680 NMGGKSTYIR 690 QTGVVVLMAQ 700 IGCFVPCESA 710 EVSIVDCILA 720 RVGAGDSQLK 730 GVSTFMAEML 740 ETASILRSAT 750 KDSLIIIDEL 760 GRGTSTYDGF 770 GLAWAISEYI 780 ATKIGAFCMF 790 ATHFHELTAL 800 ANQIPTVNNL 810 HVTALTTEET 820 LTMLYQVKKG 830 VCDQSFGIHV 840 AELANFPRHV 850 IECAKQKALE 860 LEEFQNIGAP 870 QEHDEMEPAA 880 KRCYLEREQG 890 EKIIQEFVSK 900 VKQVPFTEMS 910 EENITMKLKQ 920 LKAEVERLRV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0032301 MutSalpha complex
Cellular Component GO:0032302 MutSbeta complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0043531 ADP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140664 ATP-dependent DNA damage sensor activity
Molecular Function GO:0019237 centromeric DNA binding
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0032181 dinucleotide repeat insertion binding
Molecular Function GO:0008047 enzyme activator activity
Molecular Function GO:0000400 four-way junction DNA binding
Molecular Function GO:0032137 guanine/thymine mispair binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0030983 mismatched DNA binding
Molecular Function GO:0032405 MutLalpha complex binding
Molecular Function GO:0032357 oxidized purine DNA binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0032142 single guanine insertion binding
Molecular Function GO:0032143 single thymine insertion binding
Molecular Function GO:0003697 single-stranded DNA binding
Biological Process GO:0006301 DNA damage tolerance
Biological Process GO:0043570 maintenance of DNA repeat elements
Biological Process GO:0006298 mismatch repair
Biological Process GO:0006312 mitotic recombination
Biological Process GO:0045910 negative regulation of DNA recombination
Biological Process GO:0048298 positive regulation of isotype switching to IgA isotypes
Biological Process GO:0048304 positive regulation of isotype switching to IgG isotypes
Biological Process GO:0002204 somatic recombination of immunoglobulin genes involved in immune response

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.