Search Results
Overview
| Uniprot ID | F1SR31 |
|---|---|
| Protein Name | tRNA (guanine(6)-N(2))-methyltransferase THUMP3 |
| Gene Name | THUMPD3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 477 | AVLLTQDKKCFTKAL |
Function
Catalytic subunit of the THUMPD3-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 6 (m2G6) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases. Also catalyzes the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 7 of tRNA(Trp)
Protein Sequence
10
MLFVLDTVSC
20
PRFRTRTDYI
30
QDLGSTASMS
40
DVQESTNPLL
50
DVNLLENQSS
60
TQVTESGPKS
70
ESEHLRVTIG
80
ATVPTGFEQT
90
AADEVREKLG
100
SSCKISKDRG
110
KIYFDISVES
120
LAQVHCLRSV
130
DNLFVVVQEF
140
KDYQFKETKE
150
EVLKDFEELA
160
GKLPWSDPLK
170
IWKINTRFKK
180
RKTKRKKISQ
190
NTSKEKIDNG
200
QGDKTDEKDV
210
KKEITNNVLD
220
SQILDYYENL
230
AIKEEISTLV
240
GDDLVSCKDE
250
TDESSKEETD
260
PEVLKFRVTC
270
NRAGEKHCFS
280
SNEVARDFGG
290
AVQEYFKWKA
300
DMTNFDVEVL
310
LNIHDNEVVV
320
GIALTEESLH
330
RRNITHFGPT
340
TLRSTLAYGM
350
LRLCAPQPTD
360
IIIDPMCGTG
370
AIPIEGATEW
380
SNCYHIAGDN
390
NPLAVNRAAN
400
NISSLLTKSQ
410
VKEGKLSWGL
420
PIDTVQWDIC
430
KLPLRTGSVD
440
IIVTDMPFGK
450
RMGSKKRNWD
460
LYPACLREMS
470
RVCRPGTGRA
480
VLLTQDKKCF
490
TKALSAMGHV
500
WRKVHTVWVN
510
IGGLHAAVYL
520
LKRTPQTFVH
530
PSEQDGGRSP
WCKE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0043527 | tRNA methyltransferase complex |
| Molecular Function | GO:0160117 | tRNA (guanine(6)-N2)-methyltransferase activity |
| Molecular Function | GO:0160118 | tRNA (guanine(7)-N2)-methyltransferase activity |
| Molecular Function | GO:0016423 | tRNA (guanine) methyltransferase activity |
| Molecular Function | GO:0000049 | tRNA binding |
| Biological Process | GO:0030488 | tRNA methylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.