Overview
| Uniprot ID | F1SR53 |
|---|
| Protein Name | Integrin alpha-5 |
|---|
| Gene Name | ITGA5 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 918 |
SSGPQILKCPEAECF |
| 951 |
LHFRVWAKTFLQREH |
Function
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling
Protein Sequence
10
MGSRTPGSPL
20
QAVQLRWGPR
30
RRSRLLPLLP
40
PPLLLLLLLP
50
PPLRVGGFNL
60
DAEAPAVLSG
70
PPGSFFGFSV
80
EFYRPGTDGV
90
SVLVGAPKAN
100
TSQPGVLQGG
110
AVYLCPWATS
120
PAPCTPIEFD
130
SKGSRILESS
140
PSSLEGDEPV
150
EYKSLQWFGA
160
TVRAHGSSIL
170
ACAPLYSWRT
180
EKEPLNDPVG
190
TCYLSTDNFT
200
RILEYAPCRS
210
DFSSAAGQGY
220
CQGGFSAEFT
230
KTGRVVLGGP
240
GSYFWQGQIL
250
SATQEQISES
260
YYPEYLINPV
270
QGQLQTRQAS
280
SIYDDSYLGY
290
SVAVGEFSGD
300
DTEDFVAGVP
310
KGNLTYGYVT
320
ILNGSDIRSL
330
YNFSGEQMAS
340
YFGYAVAATD
350
INGDGLDDLL
360
VGAPLLMERT
370
ADGRPQEVGR
380
VYIYLQSPAG
390
MEPAPARTLT
400
GHDEFGRFGS
410
SLTPLGDLDQ
420
DGYNDVAIGA
430
TFGGENRQGA
440
VFIFPGGPEG
450
LASKPSQVLQ
460
PLWAAGHTPD
470
FFGSALRGGR
480
DLDGNGYPDL
490
IVGSFGVDKA
500
VVYRGRPIVS
510
ASASLSIFPA
520
MFNPEERSCN
530
LEGNPVACIN
540
LSFCLNASGK
550
HVPDSIGFTV
560
ELQLDWQKQK
570
GGVRRVLFLA
580
SRQATLTQTL
590
LIQNGAREDC
600
REMKIYLRNE
610
SEFRDKLSPI
620
HIALNFSLDP
630
QAPVDSHGLR
640
PVLHYQSKSR
650
IEDKAQILLD
660
CGEDNICVPD
670
LQLEVFGDQN
680
HVYLGDKNSL
690
NLTFHAQNVG
700
EGGAYEAELR
710
VTAPPEAEYS
720
GLVRHPGNFS
730
SLSCDYFAVN
740
QSRLLVCDLG
750
NPMKAGASLW
760
SGLRFTVPHL
770
RDTKKTIQFD
780
FQILSKNLNN
790
SQSEVVSFRL
800
SVEAQAQVSL
810
NGVSKPEAVI
820
FPVSDWHPRD
830
PPQEEEDVGP
840
AVHHVYELIN
850
LGPSSISRGV
860
LELSCPQALE
870
GRQLLYVTRV
880
TGLSNCTTSH
890
PLNPQGLELD
900
PESPQHHRLQ
910
RRDAASRSPA
920
SSGPQILKCP
930
EAECFRLRCE
940
LGPLHRQESR
950
SLQLHFRVWA
960
KTFLQREHQP
970
FSLQCEAVYQ
980
ALKMPYRILP
990
RQLPQKELQV
1000
ATAVQWIKAE
1010
GSHGVPLWII
1020
ILAILVGLLL
1030
LGLLIYILYK
1040
LGFFKRSLPY
1050
GTAMEKAQLK
PPATSDA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0005911 |
cell-cell junction |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0009897 |
external side of plasma membrane |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0034674 |
integrin alpha5-beta1 complex |
| Cellular Component |
GO:0032587 |
ruffle membrane |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0005178 |
integrin binding |
| Molecular Function |
GO:0038023 |
signaling receptor activity |
| Biological Process |
GO:0001525 |
angiogenesis |
| Biological Process |
GO:0023035 |
CD40 signaling pathway |
| Biological Process |
GO:0033627 |
cell adhesion mediated by integrin |
| Biological Process |
GO:0098609 |
cell-cell adhesion |
| Biological Process |
GO:0031589 |
cell-substrate adhesion |
| Biological Process |
GO:0035987 |
endodermal cell differentiation |
| Biological Process |
GO:0034113 |
heterotypic cell-cell adhesion |
| Biological Process |
GO:0007229 |
integrin-mediated signaling pathway |
| Biological Process |
GO:2000811 |
negative regulation of anoikis |
| Biological Process |
GO:1903672 |
positive regulation of sprouting angiogenesis |
| Biological Process |
GO:1900748 |
positive regulation of vascular endothelial growth factor signaling pathway |
| Biological Process |
GO:0014850 |
response to muscle activity |
| Biological Process |
GO:0035313 |
wound healing, spreading of epidermal cells |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.