Search Results

Overview

Uniprot ID	F1SRP0
Protein Name	Structural maintenance of chromosomes protein
Gene Name	SMC2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1160	ANVLFKTKFVDGVST
411	ACKNDISKAQTEAKQ

Function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases

Protein Sequence

10 MHIKSIILEG 20 FKSYAQRTEV 30 NGFDPLFNAI 40 TGLNGSGKSN 50 ILDSICFLLG 60 ISNLSQVRAS 70 NLQDLVYKNG 80 QAGITKASVS 90 ITFDNSDKKQ 100 SPLGFEVHDE 110 ITVTRQVVIG 120 GRNKYLINGV 130 NANNTRVQDL 140 FCSVGLNVNN 150 PHFLIMQGRI 160 TKVLNMKPPE 170 ILSMIEEAAG 180 TRMYEYKKIA 190 AQKTIEKKEA 200 KLKEIKTILE 210 EEITPTIQKL 220 KEERSSYLEY 230 QKVMREIEHL 240 SHLYIAYQFL 250 LAEDTKERSA 260 EELKEMQDKI 270 LKLQEELSEN 280 DKKIKALSHE 290 IEELEKRKDK 300 ETGGILRSLE 310 DALAEAQRIN 320 TKSQSAFDLK 330 KKNLASEENK 340 RKELEKNMVE 350 DSKTLAAKEK 360 EVKKITDGLN 370 ALQEASNKDA 380 EALAAAQQHF 390 NAVSAGLSSN 400 EDGAEATLAG 410 QMMACKNDIS 420 KAQTEAKQAQ 430 MKLKHAQQEL 440 KTKQTEVKKM 450 DSGYRKDQEA 460 LEAVKKLKEK 470 LEAEMKKLNY 480 EENKEESLLE 490 KRRQLSRDIS 500 RLKETYEALL 510 ARFPNLRFAY 520 RDPEKNWNRN 530 CVKGLVASLI 540 SVKDISATTA 550 LELVAGDRLY 560 NVVVDTEVTG 570 KKLLEKGELK 580 RRYTIIPLNK 590 ISARCIAPET 600 LKIAQTLVGP 610 NNVHVALSLV 620 EYKPELQKAM 630 EFVFGTTFVC 640 DNMDNAKKIA 650 FDKRIMTRTV 660 TLGGDVFDPH 670 GTLSGGARSQ 680 AASILTKFQE 690 LKDVQDELRI 700 KENELQALEE 710 ELAHLKNTAE 720 KYRQLKQQWE 730 MKTEEADLLQ 740 TKLQQSSYHK 750 QQEELDALKK 760 IIEESEETLK 770 NTKEIQKKAE 780 EKYEVLENKM 790 KNAEAERERE 800 LKDAQRKLDS 810 AKTKADASSK 820 KMKEKQQEVE 830 AITLELEELK 840 REHASCEQQL 850 EAVNEAIKSY 860 EGQIAVVAAE 870 VAKNKESVNK 880 AQEEVTKQKE 890 VITAQDNIVK 900 AKYAEVAKHK 910 EQNNEYQLKI 920 KELDHNINKH 930 KREAEDAAAK 940 VSKMLKDYDW 950 INTDKHLFGQ 960 PNTAYDFKTT 970 NPKEASQRLQ 980 KLEEMKEKLG 990 RNVNMRAMNV 1000 LTEAEERYND 1010 LMKKKRIVEN 1020 DKSKILATIE 1030 DLDQKKNQAL 1040 NIAWQKVNKD 1050 FGSIFSTLLP 1060 GANAMLAPPE 1070 GQTVLDGLEF 1080 KVALGNTWKE 1090 NLTELSGGQR 1100 SLVALSLILS 1110 MLLFKPAPIY 1120 ILDEVDAALD 1130 LSHTQNIGQM 1140 LRTHFTHSQF 1150 IVVSLKEGMF 1160 NNANVLFKTK 1170 FVDGVSTVAR 1180 FTQCQNGKVP 1190 KETKSKTKGP K

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0000793	condensed chromosome
Cellular Component	GO:0000794	condensed nuclear chromosome
Cellular Component	GO:0000796	condensin complex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003697	single-stranded DNA binding
Biological Process	GO:0030183	B cell differentiation
Biological Process	GO:0051301	cell division
Biological Process	GO:0021987	cerebral cortex development
Biological Process	GO:0071707	immunoglobulin heavy chain V-D-J recombination
Biological Process	GO:0007076	mitotic chromosome condensation
Biological Process	GO:1905821	positive regulation of chromosome condensation
Biological Process	GO:0051984	positive regulation of chromosome segregation
Biological Process	GO:1905820	positive regulation of chromosome separation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.