Search Results

Overview

Uniprot IDF1SS24
Protein NameFibronectin
Gene NameFN1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1169 RDTPIVKKVVTPLSP
2339 HFRCDSSKWCHDNGV
249 IGDTWSKKDNRGNLL

Function

Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling

Protein Sequence

10 MLGAGPGLLL 20 LAVLSLGTTV 30 PSTGASKSKR 40 QAQQIVQPQS 50 PLVDSQRKPG 60 CYDNGKHYQI 70 NQQWERTYLG 80 SALVCTCYGG 90 SRGFNCESKP 100 EPEETCFDKY 110 TGNTYRVGDT 120 YERPKDSMIW 130 DCTCIGAGRG 140 RISCTIANRC 150 HEGGQSYKIG 160 DTWRRPHETG 170 GYMLECVCLG 180 NGKGEWTCKP 190 IAEKCFDHAA 200 GGTSYVVGET 210 WEKPYQGWMM 220 VDCTCLGEGS 230 GRITCTSRNR 240 CNDQDTRTSY 250 RIGDTWSKKD 260 NRGNLLQCIC 270 TGNGRGEWKC 280 ERHTSLQTTS 290 AGSGSFTDVR 300 TAIYQPQPHP 310 QPAPYGHCVT 320 DSGVVYSVGM 330 QWLKTQGNKQ 340 MLCTCLGNGV 350 SCQETAVTQT 360 YGGNSNGEPC 370 VLPFTYNGRT 380 FYSCTTEGRQ 390 DGHLWCSTTS 400 NYEQDQKYSF 410 CTDHTVLVQT 420 RGGNSNGALC 430 HFPFLYNNRN 440 YTDCTSEGRR 450 DNMKWCGTTQ 460 NYDADQKFGF 470 CPMAAHEEIC 480 TTNEGVMYRI 490 GDQWDKQHDM 500 GHMMRCTCVG 510 NGRGEWTCVA 520 YSQLRDQCIV 530 DDITYNVNDT 540 FHKRHEEGHM 550 LNCTCFGQGR 560 GRWKCDPVDQ 570 CQDSETRTFY 580 QIGDSWEKYV 590 HGVRYQCYCY 600 GRGIGEWHCQ 610 PLQTYPGTTG 620 PVQVIITETP 630 SQPNSHPIQW 640 NAPEPSHISK 650 YILRWKPKNS 660 PNRWKEATIP 670 GHLNSYTIKG 680 LRPGVVYEGQ 690 LISVQHYGHR 700 EVTRFDFTTT 710 STSSAVTSNT 720 VVGETTPFSP 730 VVATSESVTE 740 ITASSFVVSW 750 VSASDTVSGF 760 RVEYELSEEG 770 DEPQYLDLPS 780 TATSVNIPDL 790 LPGRKYIVNV 800 YQISEEGEQS 810 LILSTSQTTA 820 PDAPPDPTVD 830 QVDDTSIVVR 840 WSRPQAPITG 850 YRIVYSPSVE 860 GSSTELNLPE 870 TANSVTLSDL 880 QPGVQYNITI 890 YAVEENQEST 900 PVFIQQETTG 910 VPRPDKVPPP 920 KDLQFVEVTD 930 VKVTIMWTPP 940 ESPVTGYRVD 950 VIPVNLPGEH 960 GQRLPISRNT 970 FAEVTGLSPG 980 VTYHFKVFAV 990 NQGRESKPLT 1000 AQQTTKLDAP 1010 TNLQFINETD 1020 STVMVTWTPP 1030 RARIAGYRLT 1040 VGLTRGGQPK 1050 QYNVGPSASQ 1060 YLLRNLQPGS 1070 EYAVTLVAVK 1080 GNQQSPRATG 1090 VFTTLQPVGS 1100 IPPYNTEVTE 1110 TTIVITWTPA 1120 PRIGFKLGVR 1130 PSQGGEAPRE 1140 VTSDSGSIVV 1150 SGLTPGVEYV 1160 YTISVLRDGQ 1170 ERDTPIVKKV 1180 VTPLSPPTNL 1190 HLEANPDTGV 1200 LTVSWERSTT 1210 PDITGYRITT 1220 TPTNGQQGYS 1230 LEEVVHADQS 1240 SCTFENLSPG 1250 LEYNVSVYTV 1260 KNDKESVPIS 1270 DTIIPEVPQL 1280 TDLSFVDITD 1290 SSIGLRWTPI 1300 NSSTIIGYRI 1310 TVVAAGEGIP 1320 IFEDFADSSV 1330 GYYTVTGLEP 1340 GIDYDISVIT 1350 LINGGESAPT 1360 TLTQQTAVPP 1370 PTDLRFTNVG 1380 PDTIRVTWAP 1390 PPSIELTNFL 1400 VRYSPVKNEE 1410 DVAELSISPS 1420 DNAVVLTNLL 1430 PGTEYLVSVS 1440 SVYEQHESIP 1450 LRGRQKTGLD 1460 SPTGIDFSDI 1470 TANSFTVYWI 1480 APRATITGYK 1490 IRHHPEHMGG 1500 RPREDRVPPS 1510 RNSITTNLIP 1520 GVEYVVSIVA 1530 VNGREESPPL 1540 VGQQSTVSDV 1550 PRDLQVIATT 1560 PTSLLISWDA 1570 PAVTVRYYRI 1580 TYGETGGNSP 1590 VQEFTVPGSK 1600 STATISGLKP 1610 GVDYTITVYA 1620 VTGRGDSPAS 1630 SKPVSIDYRT 1640 EIDKPSQMQV 1650 TDVQDNSISV 1660 RWLPSSSHVT 1670 GYRVTTTPKN 1680 GSGPSKTKTV 1690 GPDQTEMTIE 1700 GLQPTVEYVV 1710 SVYAQNQNGE 1720 SQPLVQTAVT 1730 NIDRPKGLAF 1740 TDVDVDSIKI 1750 AWESPQGQVS 1760 RYRVTYSSPE 1770 DGIHELFPAP 1780 DGEEDTAELQ 1790 GLRPGSEYTV 1800 SVVALHDDME 1810 SQPLIGTQST 1820 AIPAPTNLKF 1830 TQVTPTSLTA 1840 QWTAPNVQLT 1850 GYRVRVTPKE 1860 KTGPMKEINL 1870 APDSSSVVVS 1880 GLMVATKYEV 1890 SIYALKDTLT 1900 SRPAQGVVTT 1910 LENVSPPRRA 1920 RVTDATETTI 1930 TISWRTKTET 1940 ITGFQVDAVP 1950 ANGQTPIQRT 1960 IKPDVRSYTI 1970 TGLQPGTDYK 1980 IYLYTLNDNA 1990 RSSPVVIDAS 2000 TAIDAPSNLR 2010 FLATTPNSLL 2020 VSWQPPRAKI 2030 TGYIIKYEKP 2040 GSPPREVVPR 2050 PRPGVTEATI 2060 TGLEPATEYT 2070 IQVIALKNNQ 2080 KSEPLIGRKR 2090 TDELPQLVTL 2100 PHPNLHGPEI 2110 LDVPSTVQKT 2120 PFVTKPGYDT 2130 GNGIQLPGTS 2140 GQQPSLGQQM 2150 IFEEHGFRRT 2160 TPPTTATPVR 2170 HRPGPYTPNV 2180 NEEIQVGHVP 2190 RGDVDHHLYP 2200 HVLGLNPNAS 2210 TGQEALSQTT 2220 ISWTPFQESS 2230 EYIISCHPVG 2240 IDEEPLQFRV 2250 PGTSASATLT 2260 GLTRGATYNI 2270 IVEALKDQKR 2280 HKIREEVVTV 2290 GNSVDQGLSQ 2300 PTDDSCFDPY 2310 TVSHYAIGEE 2320 WERLSESGFK 2330 LSCQCLGFGS 2340 GHFRCDSSKW 2350 CHDNGVNYKI 2360 GEKWDRQGEN 2370 GQMMSCTCLG 2380 NGKGEFKCDP 2390 HEATCYDDGK 2400 TYHVGEQWQK 2410 EYLGAICSCT 2420 CFGGQRGWRC 2430 DNCRRPGAEL 2440 GPEGSTGHSY 2450 NQYSQRYHQR 2460 TNTNVNCPIE 2470 CFMPLDVQAD IEDSRE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005577 fibrinogen complex
Molecular Function GO:0008201 heparin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0016504 peptidase activator activity
Molecular Function GO:0002020 protease binding
Molecular Function GO:0043394 proteoglycan binding
Molecular Function GO:0048018 receptor ligand activity
Biological Process GO:0006953 acute-phase response
Biological Process GO:0051702 biological process involved in interaction with symbiont
Biological Process GO:0072378 blood coagulation, fibrin clot formation
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0007044 cell-substrate junction assembly
Biological Process GO:0035987 endodermal cell differentiation
Biological Process GO:0043542 endothelial cell migration
Biological Process GO:0048484 enteric nervous system development
Biological Process GO:0007507 heart development
Biological Process GO:0033622 integrin activation
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0150102 negative regulation of monocyte activation
Biological Process GO:0071635 negative regulation of transforming growth factor beta production
Biological Process GO:0007399 nervous system development
Biological Process GO:1901166 neural crest cell migration involved in autonomic nervous system development
Biological Process GO:0048146 positive regulation of fibroblast proliferation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0070372 regulation of ERK1 and ERK2 cascade
Biological Process GO:0014850 response to muscle activity
Biological Process GO:0034446 substrate adhesion-dependent cell spreading

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.