Search Results

Overview

Uniprot ID	F1SSP1
Protein Name	WD repeat and HMG-box DNA-binding protein 1
Gene Name	WDHD1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1108	KENLNLPKKQKPLNL
208	LLAVPVEKSVKLYRR
963	NEKSPVIKPLVPKPK
972	LVPKPKSKQASAASF

Function

Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork

Protein Sequence

10 MPATQKPMRY 20 GHTEGHTDVC 30 FDDSGSCIVT 40 CGSDGDVRIW 50 EDLDDDDPKS 60 INVGEKAYSC 70 ALKNGKLVTA 80 VSNNTIQVHT 90 FPEGVPDGIL 100 TRFTTNANHV 110 IFNEDGTKIA 120 AGSSDFLVKV 130 VDVMDCSQQK 140 TFRGHDAPVL 150 SLSFDPKDIF 160 LASSSCDGSV 170 KVWQISDQTC 180 AISWPLLQKC 190 NDVINAKSIC 200 RLAWQPKSGK 210 LLAVPVEKSV 220 KLYRRETWSN 230 QFDLSDNFIS 240 QTLNIVTWSP 250 CGQYLAAGSI 260 NGLIIVWNVE 270 TKDCMERVKH 280 EKGYAICGLS 290 WHPTCGQIAY 300 TDAEGNLGLL 310 ENVCDPNGKM 320 SGSKVSSRVE 330 RDYNDLFDGD 340 DTGNVGDFPN 350 DNAVETHSFS 360 KETRNDEEDD 370 DDLMLASGRP 380 RQRSHILEDD 390 ENSVDVTMLK 400 TGSSRLKEEE 410 EDDQAGNIHS 420 LPLITSQKPF 430 YDGPMPTPRQ 440 KPFQSGSTPL 450 HLTHRFMVWN 460 SIGIIRCYND 470 EQDNAIDVEF 480 HDTSIHHATH 490 LSNTLNYTVA 500 DLSHEAILLA 510 CESTDELASK 520 LHCLHFSSWD 530 SSKEWIVDMP 540 PNEDIEAVCL 550 GQGWAAAATS 560 SLLLRLFTIG 570 GVQKEVFSLP 580 GPVVSMAGHG 590 EQLIIVYHRG 600 TGFDGDQCLG 610 IQLLQLGKKK 620 KQILHGDPLP 630 LTRKSYLVWL 640 GFSAEGTPCY 650 VDSEGIVRML 660 NRGLGYTWTP 670 ICNTREHCKG 680 KSDHYWVVGI 690 HENPQHLRCI 700 PCKGSRFPPT 710 LPRPAIAVLS 720 FKLPYCQTGT 730 EKGQMEEQYW 740 RSVLFHNHLD 750 YLAKSGYEYE 760 ESTKNQAIKE 770 QQELLMKMLA 780 LSCKLEREFR 790 CVELADLMTQ 800 NAVNLAIKYA 810 SRSRRLILAQ 820 KLSELAVEKA 830 AELAAPQAEE 840 EEEEEEDFRK 850 KLNAGYSNTP 860 TEWSQPRLRN 870 RVEEDTEDTE 880 EVDDIEEKPE 890 IHKHRQNPFF 900 KSADSTDVPA 910 IKSGAVTSSS 920 QGRINPFKVS 930 GSSKEPANSF 940 SSVRSTNILD 950 NMNKSKKSAL 960 NRATNNEKSP 970 VIKPLVPKPK 980 SKQASAASFF 990 QKRTSQTDKT 1000 EEIKEENTKN 1010 SSSETPAVCP 1020 QNTENQRPKT 1030 GFQMWLEENR 1040 SNILSDNPDF 1050 SDEADIIKEG 1060 MVRFRVLSAE 1070 ERKAWAAKAK 1080 GGIASDGAEE 1090 KKRKRVVDES 1100 HETENQEEKT 1110 KENLNLPKKQ 1120 KPLNLSANQK LSAFAFKQE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0043596	nuclear replication fork
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003677	DNA binding
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0006261	DNA-templated DNA replication
Biological Process	GO:0000278	mitotic cell cycle

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.