Search Results

Overview

Uniprot IDF1ST43
Protein Name-
Gene NameACADVL
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
187 GILLFGTKAQKEKYL
290 VTHGPPEKKMGIKAS
364 NRTQFGEKIHNFGVI
374 NFGVIQEKLARMAML
548 VKLIKHKKDIVNEQF
631 RNFKSISKALIERGG

Function

Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on fatty acyl-CoAs with saturated 12 to 24 carbons long primary chains

Protein Sequence

10 MQAAKMTPNV 20 GRQLLSSRLS 30 ALPEQPRPGP 40 AWRPYAHGAA 50 QTKPDALSSE 60 ASTREKRIQT 70 ESKSFAVGMF 80 KGQLTTDQVF 90 PYPSVLNEDQ 100 TQVLQELVGP 110 VSRFFEEVND 120 PAKNDMLERV 130 EETTMQGLKE 140 LGAFGLQVPS 150 ELGGVGLCNT 160 QYARLVEIVG 170 MHDLGVGIVL 180 GAHQSIGFKG 190 ILLFGTKAQK 200 EKYLPKVASG 210 EVMAAFCLTE 220 PSSGSDAASI 230 RSSAVPSPCG 240 KYYTLNGSKI 250 WISNGGLADL 260 FTVFAKTPVT 270 DPATGAVKEK 280 ITAFLVERGF 290 GGVTHGPPEK 300 KMGIKASNTA 310 EVYFDEVQVP 320 TENVLGEVGG 330 GFKVAMHILN 340 NGRFGMAAAM 350 AGTMKAIIAK 360 AVNHAANRTQ 370 FGEKIHNFGV 380 IQEKLARMAM 390 LQYVTESMAY 400 MVSANMDQGS 410 TDFQIEAAIS 420 KIFGSEAAWK 430 VTDECIQVMG 440 GMGFMKEPGV 450 ERVLRDLRIF 460 RIFEGTNDIL 470 RLFVALQGCM 480 DKGKELSGLG 490 NALKNPFGNA 500 GLLLGEASKQ 510 LRRRAGLGSG 520 LSLSGIIHPE 530 LSRSGQLAVQ 540 ALEQFATVVE 550 VKLIKHKKDI 560 VNEQFVLQRL 570 ADSAIDLYAM 580 VVVLSRASRS 590 LSEGQSTAQH 600 EKMLCDSWCI 610 EAAARIRENM 620 AALQSDPQQQ 630 ELFRNFKSIS 640 KALIERGGVV TSNPLGV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Molecular Function GO:0000062 fatty-acyl-CoA binding
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Molecular Function GO:0017099 very-long-chain fatty acyl-CoA dehydrogenase activity
Biological Process GO:0006635 fatty acid beta-oxidation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.