Overview
| Uniprot ID | F1SU22 |
|---|
| Protein Name | UDP-glucuronic acid decarboxylase 1 |
|---|
| Gene Name | UXS1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 235 |
RACYDEGKRVAETMC |
Function
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis. Catalyzes the synthesis of UDP-xylose in two steps: the hydroxyl group of UDP-glucuronic acid is first oxidized using an enzyme-bound NAD(+) as electron acceptor, favoring the decarboxylation yielding a UDP-4-ketoxylose reaction intermediate and a reduced cofactor NADH bound to the catalytic pocket. In the second step, the 4-keto group is reduced resulting in UDP-xylose and the restoration of the enzyme to its NAD(+)-bound form
Protein Sequence
10
MLSQALLRLA
20
SAVSRRRMKL
30
LLGIALLAYV
40
ASVWGNLVNM
50
RSLQENGDLR
60
IESKIEEIVE
70
PLREKIRDLE
80
KSFTQKYPPV
90
KFLSEKDRKR
100
ILITGGAGFV
110
GSHLTDKLMM
120
DGHEVTVVDN
130
FFTGRKRNVE
140
HWIGHENFEL
150
INHDVVEPLY
160
IEVDQIYHLA
170
SPASPPNYMY
180
NPIKTLKTNT
190
IGTLNMLGLA
200
KRVGARLLLA
210
STSEVYGDPE
220
VHPQTEDYWG
230
HVNPVGPRAC
240
YDEGKRVAET
250
MCYAYMKQEG
260
VEVRVARIFN
270
TFGPRMHMND
280
GRVVSNFILQ
290
ALQGEPLTVY
300
GSGSQTRAFQ
310
YVSDLVNGLV
320
ALMNSNVSSP
330
VNLGNPEEHT
340
ILEFAQLIKN
350
LVGSGSEIQF
360
LSEAQDDPQK
370
RKPDIKKAKL
380
MLGWEPVVPL
390
EEGLNKAIHY
400
FRKELEYQAN
410
NQYIPKPKPA
420
RIKKGRTRHN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:1902494 |
catalytic complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0032580 |
Golgi cisterna membrane |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Molecular Function |
GO:0070403 |
NAD+ binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0048040 |
UDP-glucuronate decarboxylase activity |
| Biological Process |
GO:0042732 |
D-xylose metabolic process |
| Biological Process |
GO:0006024 |
glycosaminoglycan biosynthetic process |
| Biological Process |
GO:0033320 |
UDP-D-xylose biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.