Search Results
Overview
| Uniprot ID | F1SU97 |
|---|---|
| Protein Name | Prosaposin |
| Gene Name | PSAP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 372 | TARVTPLKDGGFCEV |
| 455 | GACPSAHKPLLGTEK |
Function
Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling
Protein Sequence
10
ALASPVLGLR
20
ECTRGSAVWC
30
QNVKTASDCG
40
ALQHCLQTVW
50
NKPTVKSLPC
60
DICKDVITAA
70
GDMLKDNATE
80
QEILVYLERT
90
CDWLPKPNMS
100
ATCKEIVDSY
110
FPVILDMIKG
120
QMSKPGEVCS
130
ALNLCESLQK
140
HLAELTQQKQ
150
LESNQIPELD
160
LAEAVAPFMA
170
NIPLLLYPQD
180
GSSSKPRPKA
190
DGDVCQDCIQ
200
MVTDLQNAVR
210
TNSTFVEALV
220
NHAKEECDRL
230
GPGMADMQPK
240
DICGLVGFCE
250
EVKEVPMQTL
260
VPAKVLSEKV
270
ISALELVEPI
280
KKDLVPEKAT
290
IYCEVCEFVV
300
KEVAKLIDNN
310
RTEEEIIHAL
320
DKVCSKLPTS
330
MSEECQELVD
340
TYGSSILSLL
350
LQEASPELVC
360
SMLHLCSTQG
370
LPVLTARVTP
380
LKDGGFCEVC
390
KRLVSYLDRN
400
LEKNSTKQEI
410
LAALEKGCSF
420
LPDPYQKQCD
430
QFVTEYEPVL
440
VEILVEVMEP
450
SFVCSKIGAC
460
PSAHKPLLGT
470
EKCVWGPSFW
480
CQNMESAALC
490
NAVEHCKRHV
WN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005615 | extracellular space |
| Biological Process | GO:0006665 | sphingolipid metabolic process |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0016020 | membrane |
| Biological Process | GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| Biological Process | GO:0019216 | regulation of lipid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.