Search Results
Overview
| Uniprot ID | F1SUP2 |
|---|---|
| Protein Name | Signal peptidase complex subunit 2 |
| Gene Name | SPCS2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 132 | AKKVLLEKYKYVENF |
Function
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site
Protein Sequence
10
MAGASDYYKS
20
QQAPRPLPLA
30
TSRQPALNYG
40
SRCTPRGTPR
50
RQFQPISFGQ
60
VGGEGDAQAG
70
KMAAAAAQGG
80
RSGGGGGSSG
90
AGGGPSCGTG
100
SSRSGLLDKW
110
KIDDKPVKID
120
KWDGSAVKNS
130
LDDSAKKVLL
140
EKYKYVENFG
150
LIDGRLTICT
160
ISCFFAIVAL
170
IWDYMHPFPE
180
SKPVLALCVI
190
SYPLKSGLFS
200
TDSFLKSLRI
210
IFLVAHRKDP
220
TGMDPDDIWQ
230
LSSSLKRFDD
240
KYTLKLTFIS
250
GRTKQQREAE
260
FTKSIAKFFD
270
HSGTLVMDAY
280
EPEISRLHDS
LATERKIK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005787 | signal peptidase complex |
| Molecular Function | GO:0008233 | peptidase activity |
| Biological Process | GO:0045047 | protein targeting to ER |
| Biological Process | GO:0006465 | signal peptide processing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.