Search Results

Overview

Uniprot ID	F1SUZ2
Protein Name	Nuclear pore complex protein Nup98-Nup96
Gene Name	NUP98
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
499	PATRVRPKALQTTGT
774	KTSRCLIKSPDRLAD

Function

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body)

Protein Sequence

10 MFNKSFGTPF 20 GGGTGGFGTT 30 STFGQNTGFG 40 TTSGGAFGTS 50 AFGSSNNTGS 60 LFGNSQTKPG 70 GLFGTNSFSQ 80 PATPQALALG 90 LAHQQEHQTA 100 CLELQAQGPV 110 FSHPKTMPLH 120 KINQQALGPP 130 TGTDTMVKAG 140 VSTNISTKHQ 150 CITAMKEYES 160 KSLEELRLED 170 YQANRKGPQN 180 QVGAGTATGL 190 FGSSPATSSA 200 AGLFSSSTTN 210 SSFAYGQNKT 220 AFGTSTTGFG 230 TNPGGLFGQQ 240 NQQNTSLFSK 250 PFAQAITTQT 260 TGFSFGNTST 270 LGQPSTNTMG 280 LFGVTQASQP 290 GGLFGTATNT 300 STGTAFGTGT 310 GLFGQTSTGF 320 GAVGSTLFGS 330 NKLTSFGTST 340 TSAPSFGTTS 350 GGLFGFGTNT 360 SGNSIFGSKP 370 GPGTLGPGLG 380 AGFGTALGAG 390 QASLFGNNQP 400 KLGGPLGTGA 410 FGAPGFNTTT 420 ATLGFGAPQA 430 PVALADPNAS 440 AAQQAVLQQH 450 INSLTYSPFG 460 DSPLFRNPMS 470 DPKKKEERLK 480 PTNPAAQKAL 490 TTPTHYKLTP 500 RPATRVRPKA 510 LQTTGTAKSQ 520 LFDGLDDDEP 530 SLANGAFMPK 540 KSIKKLVLKN 550 LNSSNLFSPV 560 NRDSEDLASP 570 SDYPENGERF 580 NFMSKPVEEN 590 HQQDGDDDSL 600 VSRFYTNPVA 610 KPIPQTPESA 620 GNKHNSSNSV 630 DDTIVALNMR 640 AALRNGLEGS 650 SEETSFHEES 660 LQDDREELEN 670 NAYHMHPAGI 680 VLTKVGYYTI 690 PSMDDLAKIT 700 NEKGECVVSD 710 FTIGRKGYGS 720 IYFEGDVNLT 730 NLNLDDIVHI 740 RRKEVIVYLD 750 DNQKPPVGEG 760 LNRKAEVTLD 770 GVWPTDKTSR 780 CLIKSPDRLA 790 DINYEGRLEA 800 VSRKQGAQFK 810 EYRPETGSWV 820 FKVSHFSKYG 830 LQDSDEEEEE 840 RPSKTSTKKL 850 KTAPLPPAGQ 860 AAPFQMALNG 870 KPAPPPQSQS 880 PEVEQLGRVV 890 ELDSDMVDIT 900 QEPVLDSMLE 910 ESVPEDQEPV 920 SASTHIASSL 930 GINPHVLQIM 940 KASLLADEED 950 ADMVLDQRFS 960 RLPSKADTSQ 970 EICSPRLPIS 980 AAHSSKSRSL 990 VGGLLQSKFT 1000 SGTFLSPSAS 1010 LQESRTPRAS 1020 SWMKIPPAAP 1030 WSAPPPLTSA 1040 FTVPSPAPEV 1050 PLKTVGTRRQ 1060 PGLVPLEKSV 1070 TYGKGRLLMD 1080 MALFMGRSFR 1090 VGWGPNWTLA 1100 NSGEQLSGSQ 1110 ELEHHQTTDS 1120 MEYGFLPNAV 1130 AVKSLTESPF 1140 KVHLEKLSLR 1150 QKKLDEDLQL 1160 YQTPLELKLK 1170 HSTVHVDELC 1180 PLIVPNPGVA 1190 VIHDYADWVK 1200 EASGDLLEAQ 1210 IVKHWSLTWT 1220 LCEALWGHLK 1230 ELDSQLDEPS 1240 EYVQILERRR 1250 AFSRWLSHTA 1260 APQIEEEVSL 1270 TRKDNPVEAV 1280 FSFLTGKRIS 1290 EACSLAQQSG 1300 DHRLALLLSQ 1310 LVGSQSVREL 1320 LTMQLVDWHQ 1330 LQADCFIQDE 1340 RLRVFALLAG 1350 KPVWQLSEQK 1360 HINVCSQLDW 1370 KRSLAVHLWY 1380 LLPPTASISR 1390 ALSMYEEAFQ 1400 DTSEGDRYAC 1410 CPLPSYLEGS 1420 GYMVEEEQDS 1430 QRPLQDVCFH 1440 LLKLYSDRHY 1450 DLSQLLEPRS 1460 VTADPLDYRL 1470 SWHLWEVLRA 1480 LNYTHLSEQC 1490 EGVLQASYAG 1500 QLESEGLWEW 1510 AVFVLLHIDN 1520 SSIREKAVRE 1530 LLTRHCQLLE 1540 TPESWAKEAF 1550 LTQKLCVPAE 1560 WIHEAKAVRA 1570 HMESDKHLEA 1580 LYLFKAGHWN 1590 RCHKLVIRHL 1600 ASDAIINENY 1610 DYLKGFLEDL 1620 APPERSSLIQ 1630 DWETSGLVYL 1640 DYIRVIEMLR 1650 RIQQVDCSGY 1660 ELEQLHTKVT 1670 SLCTRIEQIQ 1680 CHNAKDRLAQ 1690 SDMAKRVANL 1700 LRVVLSLQHA 1710 PDAASESTPD 1720 PQRVPLRLLA 1730 PHIGRLPMPE 1740 DYALEELRSL 1750 TQSYLRELTV GSQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0042405	nuclear inclusion body
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0034399	nuclear periphery
Cellular Component	GO:0044614	nuclear pore cytoplasmic filaments
Cellular Component	GO:0044615	nuclear pore nuclear basket
Cellular Component	GO:0031080	nuclear pore outer ring
Cellular Component	GO:1990904	ribonucleoprotein complex
Molecular Function	GO:0140693	molecular condensate scaffold activity
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0008139	nuclear localization sequence binding
Molecular Function	GO:1990841	promoter-specific chromatin binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0008236	serine-type peptidase activity
Molecular Function	GO:0017056	structural constituent of nuclear pore
Molecular Function	GO:0003713	transcription coactivator activity
Biological Process	GO:0051028	mRNA transport
Biological Process	GO:0051292	nuclear pore complex assembly
Biological Process	GO:0048026	positive regulation of mRNA splicing, via spliceosome
Biological Process	GO:0000973	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
Biological Process	GO:0006606	protein import into nucleus
Biological Process	GO:0006508	proteolysis
Biological Process	GO:0006405	RNA export from nucleus
Biological Process	GO:0034398	telomere tethering at nuclear periphery

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.