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Overview

Uniprot IDF1SV18
Protein Name-
Gene NamePOGLUT3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
160 RTLSCPTKEPQIAKD
418 WKHYVPIKRNLSDLL

Function

Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway

Protein Sequence

10 MRRLPRAALL 20 QLQLVLLVAA 30 GPPEAPVSAP 40 RSLVWGPGLR 50 AGVVLPVRYF 60 YLQAVSPEGH 70 NLTRSPPGQT 80 PFKVVIKSLS 90 PKEIVRIHVP 100 KPLDRNDGTF 110 LMRYRMYETV 120 NEGLKIEVLY 130 GDEHVAQSPY 140 ILKGPVYHEY 150 CECPEEDPQA 160 WQRTLSCPTK 170 EPQIAKDFAS 180 FPSINLQQML 190 NEIPRRFGEE 200 RGAIVHYTIL 210 NNHIYRRSLG 220 KYTDFKMFSD 230 EILLSLARKV 240 LLPDVEFYVN 250 LGDWPLEHRK 260 VNETPGPLPI 270 ISWCGSLDSR 280 DVILPTYDIT 290 HSTLEAMRGV 300 TNDLLSIQGH 310 TGPSWINKTE 320 KAFFRGRDSR 330 EERLQLVQLS 340 KENPQLLDAG 350 ITGYFFFQEK 360 EKELGKAKLI 370 GFFDFFKYKY 380 QVNVDGTVAA 390 YRYPYLMLGD 400 SLVLKQDSPY 410 YEHFYMALKP 420 WKHYVPIKRN 430 LSDLLEKIEW 440 AKEHDEEAKK 450 IAKEGQLTAR 460 DLLQPHRLYC 470 YYYRVLQKYA 480 ERQTSKPEIR 490 DGMELVPQPD 500 DSSSICQCHR KTPLREEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0012505 endomembrane system
Molecular Function GO:0046527 glucosyltransferase activity
Molecular Function GO:0035251 UDP-glucosyltransferase activity
Molecular Function GO:0035252 UDP-xylosyltransferase activity
Biological Process GO:0180059 protein O-linked glycosylation via glucose

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.