Search Results
Overview
| Uniprot ID | F1SV89 |
|---|---|
| Protein Name | Histone deacetylase 1 |
| Gene Name | HDAC1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 220 | DIGAGKGKYYAVNYP |
| 283 | LTIKGHAKCVEFVKS |
| 412 | ISICSSDKRIACEEE |
| 432 | EEGEGGRKNSSNFKK |
| 438 | RKNSSNFKKAKRVKT |
| 457 | EKDPEEKKEVTEEEK |
| 74 | YHSDDYIKFLRSIRP |
| 8 | MAQTQGTKRKVCYYY |
Function
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins
Protein Sequence
10
MAQTQGTKRK
20
VCYYYDGDVG
30
NYYYGQGHPM
40
KPHRIRMTHN
50
LLLNYGLYRK
60
MEIYRPHKAN
70
AEEMTKYHSD
80
DYIKFLRSIR
90
PDNMSEYSKQ
100
MQRFNVGEDC
110
PVFDGLFEFC
120
QLSAGGSVAS
130
AVKLNKQQTD
140
IAVNWAGGLH
150
HAKKSEASGF
160
CYVNDIVLAI
170
LELLKYHQRV
180
LYIDIDIHHG
190
DGVEEAFYTT
200
DRVMTVSFHK
210
YGEYFPGTGD
220
LRDIGAGKGK
230
YYAVNYPLRD
240
GIDDESYEAI
250
FKPVMSKVME
260
MFQPSAVVLQ
270
CGSDSLSGDR
280
LGCFNLTIKG
290
HAKCVEFVKS
300
FNLPMLMLGG
310
GGYTIRNVAR
320
CWTYETAVAL
330
DTEIPNELPY
340
NDCFEYFGPD
350
FKLHISPSNM
360
TNQNTNEYLE
370
KIKQRLFENL
380
RMLPHAPGVQ
390
MQAIPEDAIP
400
EESGDEDEED
410
PDKRISICSS
420
DKRIACEEEF
430
SDSDEEGEGG
440
RKNSSNFKKA
450
KRVKTEDEKE
460
KDPEEKKEVT
470
EEEKTKEEKQ
480
EAKGVKEEVK
LA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016581 | NuRD complex |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0004407 | histone deacetylase activity |
| Molecular Function | GO:0141221 | histone deacetylase activity, hydrolytic mechanism |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0160008 | protein decrotonylase activity |
| Molecular Function | GO:0160216 | protein lysine delactylase activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0031507 | heterochromatin formation |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.