Search Results
Overview
| Uniprot ID | F2Z3T9 |
|---|---|
| Protein Name | Splicing factor U2AF subunit |
| Gene Name | U2af2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 70 | KPLTRGAKEEHGGLI |
Function
Necessary for the splicing of pre-mRNA
Protein Sequence
10
MSDFDEFERQ
20
LNENKQERDK
30
ENRHRKRSHS
40
RSRSRDRKRR
50
SRSRDRRNRD
60
QRSASRDRRR
70
RSKPLTRGAK
80
EEHGGLIRSP
90
RHEKKKKVRK
100
YWDVPPPGFE
110
HITPMQYKAM
120
QAAGQIPATA
130
LLPTMTPDGL
140
AVTPTPVPVV
150
GSQMTRQARR
160
LYVGNIPFGI
170
TEEAMMDFFN
180
AQMRLGGLTQ
190
APGNPVLAVQ
200
INQDKNFAFL
210
EFRSVDETTQ
220
AMAFDGIIFQ
230
GQSLKIRRPH
240
DYQPLPGMSE
250
NPSVYVPGVV
260
STVVPDSAHK
270
LFIGGLPNYL
280
NDDQVKELLT
290
SFGPLKAFNL
300
VKDSATGLSK
310
GYAFCEYVDI
320
NVTDQAIAGL
330
NGMQLGDKKL
340
LVQRASVGAK
350
NATLVSLPST
360
INQTPVTLQV
370
PGLMSSQVQM
380
GGHPTEVLCL
390
MNMVLPEELL
400
DDEEYEEIVE
410
DVRDECSKYG
420
LVKSIEIPRP
430
VDGVEVPGCG
440
KIFVEFTSVF
450
DCQKAMQGLT
460
GRKFANRVVV
470
TKYCDPDSYH
RRDFW
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000974 | Prp19 complex |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0071004 | U2-type prespliceosome |
| Cellular Component | GO:0089701 | U2AF complex |
| Molecular Function | GO:0070742 | C2H2 zinc finger domain binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0140678 | molecular function inhibitor activity |
| Molecular Function | GO:0030628 | pre-mRNA 3'-splice site binding |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0048025 | negative regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:0031397 | negative regulation of protein ubiquitination |
| Biological Process | GO:0033120 | positive regulation of RNA splicing |
| Biological Process | GO:0008380 | RNA splicing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.