Search Results
Overview
| Uniprot ID | F2Z543 |
|---|---|
| Protein Name | Prohibitin |
| Gene Name | PHB1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 202 | RARFVVEKAEQQKKA |
| 208 | EKAEQQKKAAIISAE |
Function
In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses. Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells
Protein Sequence
10
MAAKVFESIG
20
KFGLALAVAG
30
GVVNSALYNV
40
DAGHRAVIFD
50
RFRGVQDIVV
60
GEGTHFLIPW
70
VQKPIIFDCR
80
SRPRNVPVIT
90
GSKDLQNVNI
100
TLRILFRPVA
110
SQLPRIFTSI
120
GEDYDERVLP
130
SITTEILKSV
140
VARFDAGELI
150
TQRELVSRQV
160
SDDLTERAAT
170
FGLILDDVSL
180
THLTFGKEFT
190
EAVEAKQVAQ
200
QEAERARFVV
210
EKAEQQKKAA
220
IISAEGDSKA
230
AELIANSLAT
240
AGDGLIELRK
250
LEAAEDIAYQ
260
LSRSRNITYL
270
PAGQSVLLQL
PQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0035632 | mitochondrial prohibitin complex |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0001850 | complement component C3a binding |
| Molecular Function | GO:0001851 | complement component C3b binding |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0031871 | proteinase activated receptor binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0140374 | antiviral innate immune response |
| Biological Process | GO:0042113 | B cell activation |
| Biological Process | GO:0071354 | cellular response to interleukin-6 |
| Biological Process | GO:0071897 | DNA biosynthetic process |
| Biological Process | GO:0040029 | epigenetic regulation of gene expression |
| Biological Process | GO:0044830 | host-mediated perturbation of viral RNA genome replication |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:0060766 | negative regulation of androgen receptor signaling pathway |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:2000323 | negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway |
| Biological Process | GO:0042177 | negative regulation of protein catabolic process |
| Biological Process | GO:0010944 | negative regulation of transcription by competitive promoter binding |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045917 | positive regulation of complement activation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0045745 | positive regulation of G protein-coupled receptor signaling pathway |
| Biological Process | GO:0002639 | positive regulation of immunoglobulin production |
| Biological Process | GO:0032740 | positive regulation of interleukin-17 production |
| Biological Process | GO:1901224 | positive regulation of non-canonical NF-kappaB signal transduction |
| Biological Process | GO:0050847 | progesterone receptor signaling pathway |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0039529 | RIG-I signaling pathway |
| Biological Process | GO:0046718 | symbiont entry into host cell |
| Biological Process | GO:0072538 | T-helper 17 type immune response |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.