Overview
| Uniprot ID | F2Z5B1 |
|---|
| Protein Name | - |
|---|
| Gene Name | SERPINB1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 351 |
ARDLFISKVVHKSFV |
Function
Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function
Protein Sequence
10
MFLSNSSNSS
20
YYLHAERLPR
30
VFGGNWALSA
40
ELSFAMEQLS
50
AANTRFALDL
60
FRALNESNPA
70
GNIFISPFSI
80
SSALAMILLG
90
TRGNTEAQMS
100
KALHFDTVKD
110
IHSRFQSLNA
120
DINKCGASYI
130
LKLANRLFGE
140
KTYHFLPEFL
150
ASTQKTYGAE
160
LASVDFLRAS
170
EEARKAINEW
180
VKEQTEGKIP
190
ELLASGVVDS
200
ATKLVLVNAI
210
YFKGSWQEKF
220
MTEATKDAPF
230
RLNKKDSKTV
240
KMMYQKKKFP
250
FGYIKELKCR
260
VLELPYQGKD
270
LSMVILLPDS
280
IEDESTGLRK
290
IEQHLTLEKL
300
REWTKPDNLE
310
LLEVNVHLPR
320
FRLEESYDLN
330
APLARLGVQD
340
LFGSRADLTG
350
MSEARDLFIS
360
KVVHKSFVEV
370
NEEGTEAAAA
380
TAGIAVFAML
390
MPEEDFIADH
400
PFIFFIRHNP
410
SSNILFLGRL
SSP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0036464 |
cytoplasmic ribonucleoprotein granule |
| Cellular Component |
GO:0005615 |
extracellular space |
| Molecular Function |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
| Biological Process |
GO:0030336 |
negative regulation of cell migration |
| Biological Process |
GO:0032691 |
negative regulation of interleukin-1 beta production |
| Biological Process |
GO:0044342 |
type B pancreatic cell proliferation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.