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Overview

Uniprot IDF2Z5C1
Protein NameAnnexin
Gene NameANXA5
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
101 YELKHALKGAGTDEK
108 KGAGTDEKILTEIIA
309 GDTSGDYKKALLLLC
76 LKSELTGKFEKLIVA
97 LYDAYELKHALKGAG

Function

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade

Protein Sequence

10 MAQVLRGTVT 20 DFPGFDERAD 30 AETLRKAMKG 40 LGTDEESILT 50 LLTSRSNAQR 60 QEIAVAFKTL 70 FGRDLLDDLK 80 SELTGKFEKL 90 IVALMKPSRL 100 YDAYELKHAL 110 KGAGTDEKIL 120 TEIIASRTPE 130 ELRAIKQVYE 140 EEYGSSLEDD 150 VVGDTSGYYQ 160 RMLVVLLQAN 170 RDPDGRIDEA 180 QVEQDAQALF 190 QAGELKWGTD 200 EEKFITIFGT 210 RSVSHLRRVF 220 DKYMTISGFQ 230 IEETIDRETS 240 GNLEQLLLAV 250 VKSIRSIPAY 260 LAETLYYAMK 270 GAGTDDHTLI 280 RVMVSRSEID 290 LFNIRKEFRK 300 NFATSLYSMI 310 KGDTSGDYKK 320 ALLLLCGGED D

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0072563 endothelial microparticle
Cellular Component GO:0009897 external side of plasma membrane
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0012506 vesicle membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005544 calcium-dependent phospholipid binding
Molecular Function GO:0001786 phosphatidylserine binding
Biological Process GO:0050819 negative regulation of coagulation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.