Search Results

Overview

Uniprot IDF2Z5G2
Protein NameStructural maintenance of chromosomes protein
Gene NameSMC3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
616 AFKHVFGKTLICRSM
93 RRVIGAKKDQYFLDK
955 SLKQLFRKLEQCNTE

Function

Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement

Protein Sequence

10 MYIKQVIIQG 20 FRSYRDQTIV 30 DPFSSKHNVI 40 AIQFVLSDEF 50 SHLRPEQRLA 60 LLHEGTGPRV 70 ISAFVEIIFD 80 NSDNRLPIDK 90 EEVSLRRVIG 100 AKKDQYFLDK 110 KMVTKNDVMN 120 LLESAGFSRS 130 NPYYIVKQGK 140 INQMATAPDS 150 QRLKLLREVA 160 GTRVYDERKE 170 ESISLMKETE 180 GKREKINELL 190 KYIEERLHTL 200 EEEKEELAQY 210 QKWDKMRRAL 220 EYTIYNQELN 230 ETRAKLDELS 240 AKRETSGEKS 250 RQLRDAQQDA 260 RDKMEDIERQ 270 VRELKTKISA 280 MKEEKEQLSA 290 ERQEQIKQRT 300 KLELKAKDLQ 310 DELAGNSEQR 320 KRLLKERQKL 330 LEKIEEKQKE 340 LAETEPKFNS 350 VKEKEERGIA 360 RLAQATQERT 370 DLYAKQGRGS 380 QFTSKEERDK 390 WIKKELKSLD 400 QAINDKKRQI 410 AAIHKDLEDT 420 EANKEKNLEQ 430 YNKLDQDLNE 440 VKARVEELDR 450 KYYEVKNKKD 460 ELQSERNYLW 470 REENAEQQAL 480 AAKREDLEKK 490 QQLLRAATGK 500 AILNGIDSIN 510 KVLDHFRRKG 520 INQHVQNGYH 530 GIVMNNFECE 540 PAFYTCVEVT 550 AGNRLFYHIV 560 DSDEVSTKIL 570 MEFNKMNLPG 580 EVTFLPLNKL 590 DVRDTAYPET 600 NDAIPMISKL 610 RYNPRFDKAF 620 KHVFGKTLIC 630 RSMEVSTQLA 640 RAFTMDCITL 650 EGDQVSHRGA 660 LTGGYYDTRK 670 SRLELQKDVR 680 KAEEELGELE 690 AKLNENLRRN 700 IERINNEIDQ 710 LMNQMQQIET 720 QQRKFKASRD 730 SILSEMKMLK 740 EKRQQSEKTF 750 MPKQRSLQSL 760 EASLHAMEST 770 RESLKAELGT 780 DLLSQLSLED 790 QKRVDALNDE 800 IRQLQQENRQ 810 LLNERIKLEG 820 IITRVETYLN 830 ENLRKRLDQV 840 EQELNELRET 850 EGGTVLTATT 860 SELEAINKRV 870 KDTMARSEDL 880 DNSIDKTEAG 890 IKELQKSMER 900 WKNMEKEHMD 910 AINHDTKELE 920 KMTNRQGMLL 930 KKKEECMKKI 940 RELGSLPQEA 950 FEKYQTLSLK 960 QLFRKLEQCN 970 TELKKYSHVN 980 KKALDQFVNF 990 SEQKEKLIKR 1000 QEELDRGYKS 1010 IMELMNVLEL 1020 RKYEAIQLTF 1030 KQVSKNFSEV 1040 FQKLVPGGKA 1050 TLVMKKGDVE 1060 GSQSQDEGEG 1070 SGESERGSGS 1080 QSSVPSVDQF 1090 TGVGIRVSFT 1100 GKQGEMREMQ 1110 QLSGGQKSLV 1120 ALALIFAIQK 1130 CDPAPFYLFD 1140 EIDQALDAQH 1150 RKAVSDMIME 1160 LAVHAQFITT 1170 TFRPELLESA 1180 DKFYGVKFRN 1190 KVSHIDVITA 1200 EMAKDFVEDD TTHG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000775 chromosome, centromeric region
Cellular Component GO:0031981 nuclear lumen
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Biological Process GO:0051301 cell division
Biological Process GO:0051276 chromosome organization
Biological Process GO:0006281 DNA repair
Biological Process GO:0051321 meiotic cell cycle

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.