Overview
| Uniprot ID | F2Z5I0 |
|---|
| Protein Name | Gamma-aminobutyric acid receptor-associated protein-like 2 |
|---|
| Gene Name | GABARAPL2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 41 |
HRCVESAKIRAKYPD |
Function
Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1. Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation
Protein Sequence
10
ALVAEAPAPR
20
AANYGFLAAL
30
RGPRQSQGNE
40
DREHRCVESA
50
KIRAKYPDRV
60
PVIVEKVSGS
70
QIVDIDKRKY
80
LVPSDITVAQ
90
FMWIIRKRIQ
100
LPSEKAIFLF
110
VDKTVPQSSL
120
TMGQLYEKEK
130
DEDGFLYVAY
SGENTFGF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005776 |
autophagosome |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Biological Process |
GO:0006914 |
autophagy |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.