Overview
| Uniprot ID | F2Z5J1 |
|---|
| Protein Name | 26S proteasome regulatory subunit 4 |
|---|
| Gene Name | PSMC1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 24 |
DDKDKKKKYEPPVPT |
| 350 |
RPGRIDRKIEFPLPD |
| 413 |
ALRERRMKVTNEDFK |
| 420 |
KVTNEDFKKSKENVL |
| 423 |
NEDFKKSKENVLYKK |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides
Protein Sequence
10
MGQSQSGGHG
20
PGGGKKDDKD
30
KKKKYEPPVP
40
TRVGKKKKKT
50
KGPDAASKLP
60
LVTPHTQCRL
70
KLLKLERIKD
80
YLLMEEEFIR
90
NQEQMKPLEE
100
KQEEERSKVD
110
DLRGTPMSVG
120
TLEEIIDDNH
130
AIVSTSVGSE
140
HYVSILSFVD
150
KDLLEPGCSV
160
LLNHKVHAVI
170
GVLMDDTDPL
180
VTVMKVEKAP
190
QETYADIGGL
200
DNQIQEIKES
210
VELPLTHPEY
220
YEEMGIKPPK
230
GVILYGPPGT
240
GKTLLAKAVA
250
NQTSATFLRV
260
VGSELIQKYL
270
GDGPKLVREL
280
FRVAEEHAPS
290
IVFIDEIDAI
300
GTKRYDSNSG
310
GEREIQRTML
320
ELLNQLDGFD
330
SRGDVKVIMA
340
TNRIETLDPA
350
LIRPGRIDRK
360
IEFPLPDEKT
370
KKRIFQIHTS
380
RMTLADDVTL
390
DDLIMAKDDL
400
SGADIKAICT
410
EAGLMALRER
420
RMKVTNEDFK
430
KSKENVLYKK
440
QEGTPEGLYL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0008540 |
proteasome regulatory particle, base subcomplex |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0008233 |
peptidase activity |
| Molecular Function |
GO:0036402 |
proteasome-activating activity |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.