Search Results
Overview
| Uniprot ID | F2Z5J7 |
|---|---|
| Protein Name | Transcription elongation factor 1 homolog |
| Gene Name | ELOF1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 135 | HEKSCDVKMDRARNT |
Function
Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Acts as a key adapter required to anchor TC-NER factors to RNA polymerase II: stably positions UVSSA and the DCX(ERCC8) complex (also named CSA complex) on arrested RNA polymerase II, leading to neddylation and activation of the DCX(ERCC8) complex and ubiquitination of RNA polymerase II
Protein Sequence
10
TFARAGGRWE
20
PGGTGALRLR
30
GTHGAEAPRA
40
QGLGGGPARS
50
LTPPGPSPPS
60
AAAGRPGSSR
70
QEATPKPRGF
80
CYRWYPGRAL
90
VRKFNRTLFP
100
QVCPPADMGR
110
RKSKRKPPPK
120
KKMTGTLETQ
130
FTCPFCNHEK
140
SCDVKMDRAR
150
NTGVISCTVC
160
LEEFQTPITY
170
LSEPVDVYSD
180
WIDACEAANQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0008023 | transcription elongation factor complex |
| Molecular Function | GO:0000993 | RNA polymerase II complex binding |
| Biological Process | GO:0006368 | transcription elongation by RNA polymerase II |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.