Overview
| Uniprot ID | F2Z5K2 |
|---|
| Protein Name | Proteasome subunit alpha type |
|---|
| Gene Name | PSMA5 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 192 |
YHKSMTLKEAIKSSL |
| 196 |
MTLKEAIKSSLIILK |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Protein Sequence
10
MFLTRSEYDR
20
GVNTFSPEGR
30
LFQVEYAIEA
40
IKLGSTAIGI
50
QTSEGVCLAV
60
EKRITSPLME
70
PSSIEKIVEI
80
DAHIGCAMSG
90
LIADAKTLID
100
KARVETQNHW
110
FTYNETMTVE
120
SVTQAVSNLA
130
LQFGEEDADP
140
GAMSRPFGVA
150
LLFGGVDEKG
160
PQLFHMDPSG
170
TFVQCDARAI
180
GSASEGAQSS
190
LQEVYHKSMT
200
LKEAIKSSLI
210
ILKQVMEEKL
220
NATNIELATV
230
QPGQNFHMFT
240
KEELEEVIKD
I
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0019773 |
proteasome core complex, alpha-subunit complex |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0061136 |
regulation of proteasomal protein catabolic process |
| Biological Process |
GO:0006979 |
response to oxidative stress |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.