Overview
| Uniprot ID | F2Z5N9 |
|---|
| Protein Name | Protein pelota homolog |
|---|
| Gene Name | PELO |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 162 |
SMTLTRAKVEVNIPR |
| 253 |
SGHKYSLKEALCDPT |
| 84 |
QACQLRVKGTNIQEN |
Function
Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy
Protein Sequence
10
MKLVRKDIEK
20
DNAGQVTLVP
30
EEPEDMWHTY
40
NLVQVGDSLR
50
ASTIRKVQTE
60
SSTGSVGSNR
70
VRTTLTLCVE
80
AIDFDSQACQ
90
LRVKGTNIQE
100
NEYVKMGAYH
110
TIELEPNRQF
120
TLAKKQWDSV
130
VLERIEQACD
140
PAWSADVAAV
150
VMQEGLAHIC
160
LVTPSMTLTR
170
AKVEVNIPRR
180
KGNCSQHDRA
190
LERFYEQVVQ
200
GIQRHIHFDV
210
VKCVLVASPG
220
FVREQFCDYM
230
FQQAVKTDNK
240
VLLENRSKFL
250
QVHASSGHKY
260
SLKEALCDPT
270
VASRLSDTKA
280
AGEVKALDDF
290
YKMLQHEPDR
300
AFYGLKQVEK
310
ANEAMAIDTL
320
LISDELFRHQ
330
DVATRSRYVR
340
LVDSVKENAG
350
TVRIFSSLHV
360
SGEQLSQLTG
370
IAAILRFPVP
380
ELSDQEDDSS
SEED
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0022626 |
cytosolic ribosome |
| Cellular Component |
GO:1990533 |
Dom34-Hbs1 complex |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0043022 |
ribosome binding |
| Molecular Function |
GO:0170011 |
stalled ribosome sensor activity |
| Biological Process |
GO:0070651 |
nonfunctional rRNA decay |
| Biological Process |
GO:0070966 |
nuclear-transcribed mRNA catabolic process, no-go decay |
| Biological Process |
GO:0070481 |
nuclear-transcribed mRNA catabolic process, non-stop decay |
| Biological Process |
GO:0072344 |
rescue of stalled cytosolic ribosome |
| Biological Process |
GO:0032790 |
ribosome disassembly |
| Biological Process |
GO:0071025 |
RNA surveillance |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.