Search Results
Overview
| Uniprot ID | F2Z5V0 |
|---|---|
| Protein Name | RNA-splicing ligase RtcB homolog |
| Gene Name | RTCB |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 17 | QFLEKINKNCWRIKK |
| 190 | GYAWAEDKEHCEEYG |
| 206 | MLQADPNKVSARAKK |
| 285 | EKAMKRDKIIVNDRQ |
| 366 | EQHVVDGKERTLLVH |
| 492 | CHDAGISKKAIKLRP |
| 504 | LRPIAVIKG****** |
Function
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs
Protein Sequence
10
MSRSYNDELQ
20
FLEKINKNCW
30
RIKKGFVPNM
40
QVEGVFYVND
50
ALEKLMFEEL
60
RNACRGGGVG
70
GFLPAMKQIG
80
NVAALPGIVH
90
RSIGLPDVHS
100
GYGFAIGNMA
110
AFDMNDPEAV
120
VSPGGVGFDI
130
NCGVRLLRTN
140
LDESDVQPVK
150
EQLAQAMFDH
160
IPVGVGSKGV
170
IPMNAKDLEE
180
ALEMGVDWSL
190
REGYAWAEDK
200
EHCEEYGRML
210
QADPNKVSAR
220
AKKRGLPQLG
230
TLGAGNHYAE
240
IQVVDEIFNE
250
YAAKKMGIDH
260
KGQVCVMIHS
270
GSRGLGHQVA
280
TDALVAMEKA
290
MKRDKIIVND
300
RQLACARIAS
310
PEGQDYLKGM
320
AAAGNYAWVN
330
RSSMTFLTRQ
340
AFAKVFNTTP
350
DDLDLHVIYD
360
VSHNIAKVEQ
370
HVVDGKERTL
380
LVHRKGSTRA
390
FPPHHPLIAV
400
DYQLTGQPVL
410
IGGTMGTCSY
420
VLTGTEQGMT
430
ETFGTTCHGA
440
GRALSRAKSR
450
RNLDFQDVLD
460
KLADMGIAIR
470
VASPKLVMEE
480
APESYKNVTD
490
VVNTCHDAGI
500
SKKAIKLRPI
AVIKG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0072669 | tRNA-splicing ligase complex |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0044600 | protein guanylyltransferase activity |
| Molecular Function | GO:0170057 | RNA ligase (GTP) activity |
| Molecular Function | GO:0017166 | vinculin binding |
| Biological Process | GO:0036498 | IRE1-mediated unfolded protein response |
| Biological Process | GO:0070054 | mRNA splicing, via endonucleolytic cleavage and ligation |
| Biological Process | GO:0000968 | tRNA exon ligation |
| Biological Process | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.