Search Results
Overview
| Uniprot ID | F5H5D3 |
|---|---|
| Protein Name | Tubulin alpha chain |
| Gene Name | TUBA1C |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 194 | LVLDRIRKLADQCTG |
| 374 | EPANQMVKCDPRHGK |
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
Protein Sequence
10
MTAWFNGVEE
20
LGRDECFVCL
30
ELDPSNGSFL
40
NAKLYISNWI
50
LIYFTRTLQL
60
PAPFNTCTSS
70
KSRGEPGCDS
80
KRECISIHVG
90
QAGVQIGNAC
100
WELYCLEHGI
110
QPDGQMPSDK
120
TIGGGDDSFN
130
TFFSETGAGK
140
HVPRAVFVDL
150
EPTVIDEVRT
160
GTYRQLFHPE
170
QLITGKEDAA
180
NNYARGHYTI
190
GKEIIDLVLD
200
RIRKLADQCT
210
GLQGFLVFHS
220
FGGGTGSGFT
230
SLLMERLSVD
240
YGKKSKLEFS
250
IYPAPQVSTA
260
VVEPYNSILT
270
THTTLEHSDC
280
AFMVDNEAIY
290
DICRRNLDIE
300
RPTYTNLNRL
310
ISQIVSSITA
320
SLRFDGALNV
330
DLTEFQTNLV
340
PYPRIHFPLA
350
TYAPVISAEK
360
AYHEQLTVAE
370
ITNACFEPAN
380
QMVKCDPRHG
390
KYMACCLLYR
400
GDVVPKDVNA
410
AIATIKTKRT
420
IQFVDWCPTG
430
FKVGINYQPP
440
TVVPGGDLAK
450
VQRAVCMLSN
460
TTAVAEAWAR
470
LDHKFDLMYA
480
KRAFVHWYVG
490
EGMEEGEFSE
500
AREDMAALEK
510
DYEEVGADSA
DGEDEGEEY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0007017 | microtubule-based process |
Reference
PMID: N/A