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Overview

Uniprot IDF6PXU8
Protein NameDecapping nuclease
Gene NameDXO
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
21 RVAEPCNKLPRPAPS

Function

Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA

Protein Sequence

10 MEPRGTKRGA 20 AKIRVAEPCN 30 KLPRPAPSLP 40 TDPALYSGPF 50 PFYRRPSELG 60 CFSLDTQRQY 70 HGDARALRYY 80 SPPPTNGQSP 90 NFDLRDGYPD 100 RYQTRDEEVQ 110 ERLDHLLRWL 120 LEHRGQLEGR 130 LGNHPLLFSG 140 EVDCTDPQAP 150 STQPPACYVE 160 LKTSKEMHSP 170 GQWKSFYRHK 180 LLKWWAQSFL 190 LGVPNVVAGF 200 RTPEGFICSL 210 KTFPTMEMFE 220 HVRNDRDGWN 230 PSVCMNFCAA 240 FLSFAQNTVV 250 QDDPRLVYLF 260 SWEPGGPVTV 270 SEHRDAPHAF 280 LPTWYVEAMT 290 QDLPPPPKTP SPKD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004518 nuclease activity
Molecular Function GO:0000166 nucleotide binding
Molecular Function GO:0003723 RNA binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.