Search Results
Overview
| Uniprot ID | F6Q2D2 |
|---|---|
| Protein Name | Porphobilinogen deaminase |
| Gene Name | HMBS |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 64 | ILDTALSKIGEKSLF |
Function
As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact
Protein Sequence
10
MGFHQEENSP
20
KMRVIRVGTR
30
KSQLARIQTD
40
SVVATLKALY
50
PGLQFEIIAM
60
STTGDKILDT
70
ALSKIGEKSL
80
FTKELEHALE
90
RNEVDLVVHS
100
LKDLPTVLPP
110
GFTIGAVCKR
120
ECPYDAVVFH
130
PKFVGKTLET
140
LPEKSVVGTS
150
SLRRAAQLQR
160
KFPHLEFKSI
170
RGNLNTRLRK
180
LDELQEFSAI
190
ILAAAGLQRM
200
GWQNRVGQIL
210
HPEECMYAVG
220
QGALGVEVRA
230
KDQDILDLVG
240
VLHDPETLLR
250
CIAERAFLRH
260
LEGGCSVPVA
270
VHTAMKDGQL
280
YLTGGVWSLN
290
GAESMQETMQ
300
ATIHVPAQHE
310
DGPEDDPQLV
320
GITARNIPRE
330
AQLAAENLGI
340
SLATLLLNKG
350
AKNILDVARQ
LNDAH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004418 | hydroxymethylbilane synthase activity |
| Biological Process | GO:0006782 | protoporphyrinogen IX biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.