Overview
| Uniprot ID | F6Q4L6 |
|---|
| Protein Name | Mitochondrial adenyl nucleotide antiporter SLC25A24 |
|---|
| Gene Name | SLC25A24 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 458 |
KTRLAVGKTGQYSGI |
| 575 |
LFRRIISKEGIPGLY |
Function
Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways. In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides. May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium-phosphate precipitates
Protein Sequence
10
MQKPELQSVP
20
LPNLPLQMRK
30
PTGRHRRPDG
40
SSTRETEQNS
50
LLRSPGPSRP
60
HPAALSLPAR
70
AGQRQARPPT
80
SPGGRLGASS
90
SPSSGGSGHS
100
LCAEPGGAST
110
PQPAAPAAPR
120
VPGLQASRAG
130
SPRLPGPPSA
140
GPARASGTML
150
RWLRGFVLPA
160
AACQDAEPPT
170
RYETLFQKLD
180
RNGDGVVDIR
190
ELQEGLKSLG
200
IPLGQDAEEK
210
IFTTGDVNKD
220
GKLDFEEFMK
230
YLKDHEKKMK
240
LAFKSLDKNN
250
DGKIEASEIV
260
QSLQILGLTI
270
SEQQAELILR
280
SIDADGTMTV
290
DWNEWRDYFL
300
FNPVTDIEEI
310
IRFWKHSTGI
320
DIGDSLTIPD
330
EFTEDEKKSG
340
QWWRQLLAGG
350
VAGAVSRTST
360
APLDRLKVMM
370
QVHGSKSEKM
380
NIYGGFRQMV
390
KEGGIRSLWR
400
GNGTNVIKIA
410
PETAVKFWAY
420
EQYKKLLTEE
430
GQKVGTFERF
440
ISGSMAGATA
450
QTFIYPMEVL
460
KTRLAVGKTG
470
QYSGIFDCAK
480
KILKHEGMGA
490
FYKGYVPNLL
500
GIIPYAGIDL
510
AVYELLKSHW
520
LDNFAKDSVN
530
PGVMVLLGCG
540
ALSSTCGQLA
550
SYPLALVRTR
560
MQAQAMVEGA
570
PQLNMVGLFR
580
RIISKEGIPG
590
LYRGITPNFM
600
KVLPAVGISY
610
VVYENMKQTL
GVTQK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Molecular Function |
GO:0140988 |
ADP:phosphate antiporter activity |
| Molecular Function |
GO:0005347 |
ATP transmembrane transporter activity |
| Molecular Function |
GO:0140987 |
ATP:phosphate antiporter activity |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Biological Process |
GO:0015866 |
ADP transport |
| Biological Process |
GO:0015867 |
ATP transport |
| Biological Process |
GO:0071277 |
cellular response to calcium ion |
| Biological Process |
GO:0034599 |
cellular response to oxidative stress |
| Biological Process |
GO:1990544 |
mitochondrial ATP transmembrane transport |
| Biological Process |
GO:0006839 |
mitochondrial transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.