Search Results
Overview
| Uniprot ID | F6QA08 |
|---|---|
| Protein Name | Protein disulfide-isomerase |
| Gene Name | PDIA3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | VSGYPTLKIFRDGEE |
| 129 | DGIVSHLKKQAGPAS |
| 130 | GIVSHLKKQAGPASV |
| 213 | RPLHLMNKFEDKTVA |
| 217 | LMNKFEDKTVAYTEP |
| 225 | TVAYTEPKMTSGKIK |
| 273 | VDYEKNAKGSNYWRN |
| 288 | RVMMVAKKFLDAGKK |
| 294 | KKFLDAGKKLNFAVA |
| 295 | KFLDAGKKLNFAVAS |
| 346 | EEFSRDGKALERFLQ |
| 361 | DYFDGNLKRYLKSEP |
| 365 | GNLKRYLKSEPIPES |
| 414 | HCKNLEPKYKELGEK |
| 416 | KNLEPKYKELGEKLR |
| 421 | KYKELGEKLRKDPNI |
| 424 | ELGEKLRKDPNIIIA |
| 459 | IYFSPANKKLNPKKY |
| 493 | PPIIQEEKPKKKKKA |
| 75 | EAAATRLKGIVPLAK |
| 82 | KGIVPLAKVDCTANT |
| 94 | ANTNTCNKYGVSGYP |
Function
Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity
Protein Sequence
10
MRLCRLALFP
20
GVALLLAAAR
30
LAAASDVLEL
40
TDDNFESRIS
50
DTGSAGLMLV
60
EFFAPWCGHC
70
KRLAPEYEAA
80
ATRLKGIVPL
90
AKVDCTANTN
100
TCNKYGVSGY
110
PTLKIFRDGE
120
EAGAYDGPRT
130
ADGIVSHLKK
140
QAGPASVPLR
150
TEEEFKFISD
160
KDASVVGFFK
170
DLFSEAHSEF
180
LKAASNLRDN
190
YRFAHTNVES
200
LVDKYDDDGE
210
GITLFRPLHL
220
MNKFEDKTVA
230
YTEPKMTSGK
240
IKKFIQENIF
250
GICPHMTEDN
260
KDLIQGKDLL
270
LAYYDVDYEK
280
NAKGSNYWRN
290
RVMMVAKKFL
300
DAGKKLNFAV
310
ASRKTFSHEL
320
SDFGLESTAG
330
EIPVVAIRTA
340
KGEKFVMQEE
350
FSRDGKALER
360
FLQDYFDGNL
370
KRYLKSEPIP
380
ESNDGPVKVV
390
VAENFDEIVN
400
DENKDVLIEF
410
YAPWCGHCKN
420
LEPKYKELGE
430
KLRKDPNIII
440
AKMDATANDV
450
PSPYEVRGFP
460
TIYFSPANKK
470
LNPKKYEGGR
480
ELSDFISYLQ
490
REATNPPIIQ
500
EEKPKKKKKA
QEDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0042824 | MHC class I peptide loading complex |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0106222 | lncRNA binding |
| Molecular Function | GO:0003756 | protein disulfide isomerase activity |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0015035 | protein-disulfide reductase activity |
| Biological Process | GO:0002502 | peptide antigen assembly with MHC class I protein complex |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0034976 | response to endoplasmic reticulum stress |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.